NDLI: Singlet oxygen-generating from fluorescence probes based on denatured bovine serum albumin-conjugated CdTe quantum dots and photosensitizer Chlorin e6

Content Provider	Springer Nature Link
Author	Wu, Sheng Mei Sun, Xiao Juan Wang, Li Li Fei, Meng Ying Yan, Zheng Yu
Copyright Year	2014
Abstract	Based on the excellent optical properties of quantum dots (QDs), a simple and efficient method was proposed and established to produce a singlet oxygen activating QDs-denatured Bovine Serum Albumin (dBSA)-Chlorin e6 (Ce6) bioprobe. In this work, a quick synthesis of water-soluble CdTe QDs was accomplished and showed a good linear fit between synthetic heating duration and its maximum fluorescence emission wavelength. Moreover, dBSA which is a convenient and widely used agent was employed as a bridge to conjugate the selective CdTe QDs with a suitable emitting wavelength and photosensitizer Ce6, simply using N-ethyl-N-(3-dimethylaminopropyl) carbodiimide and N-hydroxy succinimide as coupling agents. UV–Vis, fluorescence, and IR spectroscopy confirmed the successful conjugation of QDs and Ce6. The as-produced QDs-dBSA-Ce6 bioconjugates demonstrated an effective fluorescence resonance energy transfer efficiency of as high as 0.90, which also proved to be well conserved of its singlet oxygen-generating in oxidation–extraction photometry tests and might be a potential bioprobe in the research of photo dynamic therapy.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	16
Issue Number	11
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-10-18
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CdTe quantum dots Chlorin e6 Singlet oxygen generation FRET Nanomedicine Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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