NDLI: A toxicity assessment of hydroxyapatite nanoparticles on development and behaviour of Drosophila melanogaster

Content Provider	Springer Nature Link
Author	Pappus, S. Aurosman Ekka, Basanti Sahu, Swetapadma Sabat, Debabrat Dash, Priyabrat Mishra, Monalisa
Copyright Year	2017
Abstract	The effects of oral intake of hydroxyapatite nanoparticles (HApNPs) were investigated on growth, development and behaviour of Drosophila. The Drosophila responses to various concentrations of HApNPs were compared. At lower concentrations, i.e. 5 mg L$^{−1}$ more amount of oxidative stress was produced than that of highest concentration, i.e. 80 mg L$^{−1}$. The increased amounts of oxidative stress reflect a higher amount of ROS production and increased cell damage within the larval gut. HApNPs was further shown to interfere with the calcium and phosphorus absorption pathway. Besides all these damage, HApNPs causes developmental delay in the late third instar larvae. The most significant anomaly was observed in pupae count, fly hatching after the feeding of HApNPs. Flies hatched from treated vials have decreased body weight with defective walking behaviour. Hatched flies have a phenotypic defect in the wing, eye and thorax of the bristles. Along with these changes, the adult fly becomes more prone towards stress. The findings hint that HApNPs persuade noxious effects and alter the development, structure, function and behaviour of the fly in a concentration-dependent manner. Graphical abstract Effect of Hydroxyapatite on the complete life cycle of Drosophila. Flies lay eggs in Hydroxyapatite containing food. As soon as the eggs hatch to larvae they start eating the NP contained food. The effect of Hydroxyapatite on various developmental stage is summerised by biochemical, immunohistochemical, behavioral, developmental and phenotypic defects.
Starting Page	1
Ending Page	16
Page Count	16
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	19
Issue Number	4
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2017-04-06
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hydroxyapatite nanoparticles Mechano-sensory neurons Drosophila melanogaster Oxidative stress Micronuclei Phosphorus absorption Environmental and health effects Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Lasers, Photonics, Optical Devices
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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