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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zhu, Shaojia Zhen, Hong Li, Yongjun Wang, Ping Huang, Xiaoyu Shi, Ping |
| Copyright Year | 2014 |
| Abstract | Graphene, a two-dimensional nanomaterial, has become a hot spot of research at the interface of nanotechnology and biomedicine. In this study, the oxidized form of graphene, graphene oxide (GO), was functionalized with 6-armed polyethylene glycol (PEG), which rendered it stable and biocompatible in physiological solution. The successful synthesis of PEGylated graphene oxide (GO-PEG) nanocarrier with low toxicity was confirmed by UV–Vis spectroscopy, Fourier-transform infrared spectroscopy, atomic force microscopy, and thermogravimetric analysis. By dynamic light scattering (DLS), the size distribution of the nanoparticles were shown to be 60–200 nm. Furthermore, a complex by loading an aromatic anticancer compound, podophyllotoxin (PPT), onto GO-PEG (GO-PEG/PPT) via π–π stacking and hydrophobic interactions was investigated. It was demonstrated that GO-PEG/PPT showed remarkably high cytotoxicity compared to free PPT in both the human cervical adenocarcinoma HeLa cell line and human hepatoma SMMC-7721 cell line. The loading and delivery of anticancer drugs using this kind of graphene-based nanocarrier may find potential application in biomedicine. |
| Starting Page | 1 |
| Ending Page | 11 |
| Page Count | 11 |
| File Format | |
| ISSN | 13880764 |
| Journal | Journal of Nanoparticle Research |
| Volume Number | 16 |
| Issue Number | 8 |
| e-ISSN | 1572896X |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2014-07-10 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Nanomaterial Graphene oxide Cytotoxicity Podophyllotoxin Drug delivery Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation |
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