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| Content Provider | Springer Nature Link |
|---|---|
| Author | Thies, William Urbanski, John Paul Thorsen, Todd Amarasinghe, Saman |
| Copyright Year | 2007 |
| Abstract | Microfluidic devices are emerging as an attractive technology for automatically orchestrating the reactions needed in a biological computer. Thousands of microfluidic primitives have already been integrated on a single chip, and recent trends indicate that the hardware complexity is increasing at rates comparable to Moore’s Law. As in the case of silicon, it will be critical to develop abstraction layers—such as programming languages and Instruction Set Architectures (ISAs)—that decouple software development from changes in the underlying device technology. Towards this end, this paper presents BioStream, a portable language for describing biology protocols, and the Fluidic ISA, a stable interface for microfluidic chip designers. A novel algorithm translates microfluidic mixing operations from the BioStream layer to the Fluidic ISA. To demonstrate the benefits of these abstraction layers, we build two microfluidic chips that can both execute BioStream code despite significant differences at the device level. We consider this to be an important step towards building scalable biological computers. |
| Starting Page | 255 |
| Ending Page | 275 |
| Page Count | 21 |
| File Format | |
| ISSN | 15677818 |
| Journal | Natural Computing |
| Volume Number | 7 |
| Issue Number | 2 |
| e-ISSN | 15729796 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2007-05-05 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Microfluidics Laboratory automation DNA computing Biological computation Self-assembly Programming languages Complexity Artificial Intelligence (incl. Robotics) Processor Architectures Evolutionary Biology Theory of Computation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Computer Science Applications |
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