NDLI: Rule-based programming for integrative biological modeling : Application to the modeling of the λ phage genetic switch

Content Provider	Springer Nature Link
Author	Michel, Olivier Spicher, Antoine Giavitto, Jean Louis
Copyright Year	2008
Abstract	Systems biology aims at integrating processes at various time and spatial scales into a single and coherent formal description to allow computer modeling. In this context, we focus on rule-based modeling and its integration in the domain-specific language MGS . Through the notions of topological collections and transformations, MGS allows the modeling of biological processes at various levels of description. We validate our approach through the description of various models of the genetic switch of the λ phage, from a very simple biochemical description of the process to an individual-based model on a Delaunay graph topology. This approach is a first step into providing the requirements for the emerging field of spatial systems biology which integrates spatial properties into systems biology.
Starting Page	865
Ending Page	889
Page Count	25
File Format	PDF
ISSN	15677818
Journal	Natural Computing
Volume Number	8
Issue Number	4
e-ISSN	15729796
Language	English
Publisher	Springer Netherlands
Publisher Date	2008-11-12
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Domain-specific languages Rule-based modeling Spatial systems biology Statistical Physics, Dynamical Systems and Complexity Artificial Intelligence (incl. Robotics) Processor Architectures Evolutionary Biology Theory of Computation
Content Type	Text
Resource Type	Article
Subject	Computer Science Applications

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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