NDLI: Comparative In Vitro Activities of Fluconazole, Voriconazole, and MXP-4509 Against Romanian Blood Yeast Isolates

Content Provider	Springer Nature Link
Author	Mareş, Mihai Năstasă, Valentin Moraru Ramona, Florina Doroftei, Bogdan Ştefanache, Alina
Copyright Year	2011
Abstract	The aim of the study was to evaluate the antifungal activity of a new triazole formulation against 182 clinical isolates of yeasts recovered from blood cultures in three tertiary hospitals in Romania and to compare its activity with those of fluconazole and voriconazole. In vitro susceptibility was assessed by following the guidelines of AFST-EUCAST E. Def. 7.1. The distribution of minimum inhibitory concentrations (MICs) of MXP-4509 was very similar to that of voriconazole (MIC$_{50}$: 0.0312 mg/l vs. 0.0156 mg/l; MIC$_{90}$: 0.25 mg/l vs. 0.25 mg/l), but significantly different from that of fluconazole (MIC$_{50}$: 0.0312 mg/l vs. 0.5 mg/l; MIC$_{90}$: 0.25 mg/l vs. 32 mg/l). The new triazole MXP-4509 proved to have a good in vitro antifungal activity raising the interest for further pharmacological and microbiological investigations in order to assess its potential advantages for therapy.
Starting Page	487
Ending Page	492
Page Count	6
File Format	PDF
ISSN	0301486X
Journal	Mycopathologia
Volume Number	172
Issue Number	6
e-ISSN	15730832
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-07-31
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antifungal activity Candida spp. Fluconazole Voriconazole MXP-4509 Microbiology Microbial Ecology Medical Microbiology Plant Sciences Eukaryotic Microbiology
Content Type	Text
Resource Type	Article
Subject	Plant Science Veterinary Microbiology Applied Microbiology and Biotechnology Agronomy and Crop Science

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