NDLI: Prevalent Drug Resistance Among Oral Yeasts from Asymptomatic Patients in Hainan, China

Content Provider	Springer Nature Link
Author	Wu, Jinyan Guo, Hong Yi, Guohui Zhou, Limin He, Xiaowen Huang, Xianxi Wang, Huamin Xue, Weiling Xu, Jianping
Copyright Year	2014
Abstract	The oral cavity is a significant niche of the human microbiome and a gateway for the microbiota in many other human body sites. As a result, understanding the oral microbiota has broad implications for the prevention and management of human infectious diseases. Opportunistic yeast infections are among the most prevalent fungal infections of humans, and most opportunistic yeast pathogens are common residents of the oral mucosa. However, relatively little is known about the drug susceptibility profiles of oral yeasts. Here, we report the species distribution and patterns of antifungal susceptibility profiles among 313 yeasts isolated from the oral cavities of 301 asymptomatic hospitalized patients in Hainan Province in southern China. These yeasts were tested for their susceptibilities to the following five drugs: amphotericin B, fluconazole, itraconazole, ketoconazole, and fluorocytosine. Since none of the sampled hosts had taken any antifungal drugs at least 3 months before samples were taken, we hypothesized that little or no drug resistance should be observed. Contrary to our expectations, our analyses identified that 29 % (91/313) of the isolates were resistant to at least one drug and 14.3 % (45/313) were resistant to two or more of the five common drugs. The potential sources of the observed resistance were discussed.
Starting Page	299
Ending Page	307
Page Count	9
File Format	PDF
ISSN	0301486X
Journal	Mycopathologia
Volume Number	177
Issue Number	5-6
e-ISSN	15730832
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-05-10
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Antifungal resistance Oral yeasts Candida Geographic differences Origin of drug resistance Microbiology Medical Microbiology Eukaryotic Microbiology Microbial Ecology Plant Sciences
Content Type	Text
Resource Type	Article
Subject	Plant Science Veterinary Microbiology Applied Microbiology and Biotechnology Agronomy and Crop Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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