NDLI: Association between tumor necrosis factor-α promoter −308 A/G, −238 A/G, interleukin-6 −174 G/C and −572 G/C polymorphisms and periodontal disease: a meta-analysis

Content Provider	Springer Nature Link
Author	Song, Gwan Gyu Choi, Sung Jae Ji, Jong Dae Lee, Young Ho
Copyright Year	2013
Abstract	The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) promoter polymorphisms confer susceptibility to periodontitis in ethnically different populations. A literature search was performed using PubMed and Embase and a meta-analysis of the identified studies was conducted to explore the associations between TNF-α −308 A/G, −238 A/G, IL-6 promoter −174 G/C and −572 G/C polymorphisms and periodontitis. Seventeen comparison studies for the TNF-α −308 A/G polymorphism and three studies for the TNF-α −238 A/G polymorphism were included in the meta-analysis. And 16 separate studies for the IL-6 −174 G/C polymorphism and 10 studies for the IL-6 −572 G/C polymorphism were considered in our meta-analysis. Analysis after stratification by ethnicity indicated that the TNF-α −308 A allele was associated with periodontitis in Brazilian, Asian, and Turkish populations (OR = 0.637, 95 % CI = 0.447–0.907, p = 0.013; OR = 0.403, 95 % CI = 0.204–0.707, p = 0.009; OR = 1.818, 95; % CI = 1.036–3.189, p = 0.037). The meta-analysis showed no association between the TNF-α −238 A/G polymorphism and periodontitis. The meta-analysis indicated an association of the IL-6 −174 G/C polymorphisms with periodontitis in Brazilian populations (OR for GG + GC = 2.394, 95 % CI = 1.081–5.302, p = 0.031). Stratification by ethnicity and disease type indicated an association between the IL-6 −572 G allele and chronic periodontitis (OR = 1.585, 95 % CI = 1.030–2.439, p = 0.036), and periodontitis in Europeans (OR = 2.118, 95 % CI = 1.254–3.577, p = 0.005). This meta-analysis demonstrates that the TNF-α −308 A/G polymorphism confers susceptibility to periodontitis in Brazilian, Asian and Turkish populations. The IL-6 −174 G/C polymorphism may confer susceptibility to periodontitis in Brazilians, and the IL-6 −572 G/C polymorphism may be associated with susceptibility to periodontitis in Europeans, and chronic periodontitis.
Starting Page	5191
Ending Page	5203
Page Count	13
File Format	PDF
ISSN	03014851
Journal	Molecular Biology Reports
Volume Number	40
Issue Number	8
e-ISSN	15734978
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-05-09
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	TNF-α IL-6 Polymorphism Periodontitis Meta-analysis Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

IL-6 gene polymorphisms and CAD risk: a meta-analysis

TNF promoter −308 A/G and −238 A/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis

CTLA-4 and TNF-α promoter-308 A/G polymorphisms and ANCA-associated vasculitis susceptibility: a meta-analysis

Associations between TNF-α −308 A/G and lymphotoxin-α +252 A/G polymorphisms and susceptibility to sarcoidosis: a meta-analysis

Association of the IL-10 polymorphisms and periodontitis: a meta-analysis

Association between TNF-α promoter G-308A and G-238A polymorphisms and obesity

Association of IL-6, TNF-α and IL-10 gene polymorphisms with type 2 diabetes mellitus

Association between TNF-α polymorphisms and cervical cancer risk: a meta-analysis

TNF- -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis.

Association between tumor necrosis factor-α promoter −308 A/G, −238 A/G, interleukin-6 −174 G/C and −572 G/C polymorphisms and periodontal disease: a meta-analysis

Similar Documents

IL-6 gene polymorphisms and CAD risk: a meta-analysis

TNF promoter −308 A/G and −238 A/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis

CTLA-4 and TNF-α promoter-308 A/G polymorphisms and ANCA-associated vasculitis susceptibility: a meta-analysis

Associations between TNF-α −308 A/G and lymphotoxin-α +252 A/G polymorphisms and susceptibility to sarcoidosis: a meta-analysis

Association of the IL-10 polymorphisms and periodontitis: a meta-analysis

Association between TNF-α promoter G-308A and G-238A polymorphisms and obesity

Association of IL-6, TNF-α and IL-10 gene polymorphisms with type 2 diabetes mellitus

Association between TNF-α polymorphisms and cervical cancer risk: a meta-analysis

TNF- -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis.

Association between tumor necrosis factor-α promoter −308 A/G, −238 A/G, interleukin-6 −174 G/C and −572 G/C polymorphisms and periodontal disease: a meta-analysis