NDLI: A miR-125b binding site polymorphism in bone morphogenetic protein membrane receptor type IB gene and prostate cancer risk in China

Content Provider	Springer Nature Link
Author	Feng, Ninghan Xu, Bin Tao, Jun Li, Pengchao Cheng, Gong Min, Zhichao Mi, Yuanyuan Wang, Meilin Tong, Na Tang, Jialin Zhang, Zhengdong Wu, Hongfei Zhang, Wei Wang, Zengjun Hua, Lixin
Copyright Year	2011
Abstract	Recently, a C>T polymorphism (rs1434536) in a miR-125b binding site in the 3′ untranslated region (3′UTR) of bone morphogenetic protein membrane receptor type IB gene (BMPR1B) has been found to contribute to cancer susceptibility. To investigate whether it plays an important role in the development of prostate cancer in southern Chinese Han population, we performed a case–control study. 247 prostate cancer and 278 control subjects were included in the cancer association study and dual-luciferase reporter assay was used to test the binding ability of miR-125b to BMPR1B-C or -T vectors. The effect of CT/TT genotype on prostate cancer risk was found to be significant for localized disease (OR = 1.60, 95% CI = 1.01–2.53, P = 0.044) and among subgroups of aged >70 years (OR = 1.90, 95% CI = 1.15–3.15, P = 0.015) compared with CC genotype. Moreover, C-allele gave a reduced luciferase activity relative to T-allele in dual-luciferase reporter assay. Our findings show that rs1434536 in the 3′UTR of BMPR1B gene affects the binding ability of miR-125b to BMPR1B mRNA and contributes to the genetic predisposition to localized prostate cancer and patients aged >70 years.
Starting Page	369
Ending Page	373
Page Count	5
File Format	PDF
ISSN	03014851
Journal	Molecular Biology Reports
Volume Number	39
Issue Number	1
e-ISSN	15734978
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-05-10
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	miR-125b BMPR1B Polymorphism Prostate cancer Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology

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