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| Content Provider | Springer Nature Link |
|---|---|
| Author | Bavec, Aljoša Jiang, Yang Langel, Ülo Zorko, Matjaž |
| Copyright Year | 2006 |
| Abstract | We have demonstrated the ability of peptides derived from the third intracellular loop of GLP-1 receptor to differently modulate activity of four different types of G-proteins overexpressed in sf9 cells. In this respect, the involvement of Cys$^{341}$ in inhibition of G$_{s}$ and Cys$^{341}$ in activation of G$_{s}$ and in inhibition of G$_{i1,}$ G$_{o}$, and G$_{11}$, respectively, indicates their potential role in discrimination between different types of G-proteins. Moreover, these two amino acids from the third intracellular loop might represent an important novel targets for covalent modification by downstream regulators in signaling through GLP-1 receptor. |
| Starting Page | 53 |
| Ending Page | 60 |
| Page Count | 8 |
| File Format | |
| ISSN | 03014851 |
| Journal | Molecular Biology Reports |
| Volume Number | 34 |
| Issue Number | 1 |
| e-ISSN | 15734978 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2006-11-14 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | G-protein-coupled receptors GLP-1 Glucagon-like peptide-1 receptor G proteins Immunoblotting Sf9 cells Animal Biochemistry Animal Anatomy / Morphology / Histology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Molecular Biology |
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