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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zheng, Guo Hua Chen, Hai Ying Xiong, Shang Quan Chu, Jian Feng |
| Copyright Year | 2010 |
| Abstract | Lipoprotein-associated phospholipase A2 (LP-PLA2) may play an important role in the pathophysiology of coronary heart disease (CHD). The polymorphism of LP-PLA2 gene caused LP-PLA2 enzyme activity depressing or lost. But there is not a definite conclusion for the association of between the LP-PLA2 gene polymorphism and CHD risk. To assess the relationship between LP-PLA2 gene V279F polymorphism and CHD, a comprehensive Meta-analysis was performed. All the case–control studies evaluating the association of between the LP-PLA2 gene V279F polymorphism and CHD risk were identified. Seven case–control studies involving 3,614 patients with CHD and 4,334 controls were included. The crude odds ratios (ORs) of meta-analysis under the different gene model were not significant. But in the stratified analysis by study size, ethnicity, cases definition, and source of controls under the additive model, the association was evident in ethnicity for Japanese group (OR = 1.38, 95%CI = 1.22–1.56), cases definition for MI (OR = 1.22, 95%CI = 1.01–1.49), source of controls for the based-hospital (OR = 1.42, 95%CI = 1.24–1.59). These data suggested that the V279F polymorphism in LP-PLA2 gene may contribute to CHD development. But there is necessary that more well-designed large studies are required for the validation of this association. |
| Starting Page | 4089 |
| Ending Page | 4099 |
| Page Count | 11 |
| File Format | |
| ISSN | 03014851 |
| Journal | Molecular Biology Reports |
| Volume Number | 38 |
| Issue Number | 6 |
| e-ISSN | 15734978 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2010-11-24 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Lipoprotein-associated phospholipase A2 (LP-PLA2) Coronary heart disease Genetic polymorphism Meta-analysis Animal Anatomy / Morphology / Histology Animal Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine Molecular Biology |
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