NDLI: Estrogen receptors and their genes—potential markers of functional and production traits of farm animals

Content Provider	Springer Nature Link
Author	Szreder, Tomasz Zwierzchowski, Lech
Copyright Year	2007
Abstract	Estrogen receptors, similarly as other nuclear receptors, are transcription factors, which after binding to a proper ligand (17β-estradiol, estron or estriol) are capable of regulating transcription of target genes. Due to the functions that estrogens play in the regulation of reproduction, development of the mammary gland, growth and differentiation of cells, estrogen receptors and their genes are considered as candidate markers for production and functional traits in farm animals. Known are two isoforms of the estrogen receptor—α and β. They are encoded by separate genes located on different chromosomes. The typical feature of all genes coding for nuclear receptors, including the ER genes, is the complex structure of their 5′ regions. In the 5′ region of the ERα gene of different species are located alternative exons that code for transcripts of different length with different 5′-UTR (untranslated region). The mRNA variants are created by the alternative splicing of the primary transcripts. We sequenced a 2853 bp of the bovine ER gene 5′ region, including exons A, B, C and their promoters. Moreover, we found several polymorphic sites, differing by single nucleotide substitutions (SNPs), in the 5′ regulatory region and in the coding region of the bovine ERα gene.
Starting Page	207
Ending Page	211
Page Count	5
File Format	PDF
ISSN	03014851
Journal	Molecular Biology Reports
Volume Number	34
Issue Number	4
e-ISSN	15734978
Language	English
Publisher	Springer Netherlands
Publisher Date	2007-07-28
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Estrogen receptor Gene Sequence Polymorphism Farm animals Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology

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