NDLI: Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels

Please wait, while we are loading the content...

Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels

Transcriptome profiling of the UV-B stress response in the desert shrub Lycium ruthenicum

Soluble overexpression and purification of bioactive human CCL2 in E. coli by maltose-binding protein

Genetic polymorphisms of the organic cation transporter 1 gene (SLC22A1) within the Cape Admixed population of South Africa

Frequency of interleukin 28B rs12979860 C>T variants in Filipino patients chronically infected with hepatitis B virus

Molecular characterisation and expression analysis of a novel calreticulin (CRT) gene in the dinoflagellate Prorocentrum minimum

Molecular docking and molecular dynamics study on SmHDAC1 to identify potential lead compounds against Schistosomiasis

Single nucleotide polymorphisms of the FTO gene and cancer risk: an overview

Selection of reference genes for quantitative real time RT-PCR during dimorphism in the zygomycete Mucor circinelloides

Serum microRNAs; miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-5p could be used as novel non-invasive biomarkers for HCV-positive cirrhosis and hepatocellular carcinoma

MiR-21 up-regulation mediates glioblastoma cancer stem cells apoptosis and proliferation by targeting FASLG

Two novel polymorphisms of bovine SIRT2 gene are associated with higher body weight in Nanyang cattle

Cloning and expression of a CYP720B orthologue involved in the biosynthesis of diterpene resin acids in Pinus brutia

Association between ABCG1 polymorphism rs1893590 and high-density lipoprotein (HDL) in an asymptomatic Brazilian population

Polymorphisms in nucleotide excision repair genes and susceptibility to colorectal cancer in the Polish population

Molecular Biology Reports : Volume 42, Issue 2, February 2015

Molecular Biology Reports : Volume 42, Issue 1, January 2015

Molecular Biology Reports : Volume 41

Molecular Biology Reports : Volume 40

Molecular Biology Reports : Volume 39

Molecular Biology Reports : Volume 38

Molecular Biology Reports : Volume 37

Molecular Biology Reports : Volume 36

Molecular Biology Reports : Volume 35

Molecular Biology Reports : Volume 34

Molecular Biology Reports : Volume 33

Molecular Biology Reports : Volume 32

Molecular Biology Reports : Volume 31

Molecular Biology Reports : Volume 30

Molecular Biology Reports : Volume 29

Molecular Biology Reports : Volume 28

Molecular Biology Reports : Volume 27

Molecular Biology Reports : Volume 26

Molecular Biology Reports : Volume 25

Molecular Biology Reports : Volume 24

Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels

Content Provider	Springer Nature Link
Author	Hromadnikova, Ilona Dvorakova, Lenka Kotlabova, Katerina Kestlerova, Andrea Hympava, Lucie votna, Veronika Doucha, Jindrich Krofta, Ladislav
Copyright Year	2014
Abstract	The study describes the stress response in the central cotyledon zone of placental tissue and in maternal whole peripheral blood to pregnancy related complications including gestational hypertension (n = 31), preeclampsia w or w/o fetal growth restriction (n = 95), and fetal growth restriction (n = 39) using real-time RT-PCR and genes encoding Hsp27, Hsp60, Hsp70, Hsp90 and HspBP1 proteins. The placental tissue does not respond to pregnancy induced hypertension, fetal growth restriction and short-term severe preeclampsia that requires immediate termination of gestation. Upregulation of Hsp27, Hsp90 and HspBP1 appears just in case of long-term deteriorated conditions (usually in mild preeclampsia, that enable further continuation of gestation, when properly treated). On the other hand, maternal circulation is able to reflect both maternal and fetal pathologic conditions. While pregnancy related complications always induce upregulation of Hsp70 and downregulation of Hsp90 in maternal whole peripheral blood, the increase of Hsp60 mRNA levels occurs entirely in patients with preeclampsia and/or fetal growth restriction. Hsp60, Hsp70 and Hsp90 are dysregulated in maternal circulation irrespective of the severity of the disease (in both mild and severe preeclampsia) and the requirements for the delivery (before and after 34th week of gestation). Nevertheless, the highest Hsp60 mRNA levels may be observed in pregnancies with signs of the centralization of the fetal circulation associated with fetal hypoxia.
Starting Page	625
Ending Page	637
Page Count	13
File Format	PDF
ISSN	03014851
Journal	Molecular Biology Reports
Volume Number	42
Issue Number	3
e-ISSN	15734978
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-10-31
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Heat shock proteins Placenta Preeclampsia Gestational hypertension Fetal growth restriction Stress response Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Placental OLAH Levels Are Altered in Fetal Growth Restriction, Preeclampsia and Models of Placental Dysfunction

Associations of maternal and placental extracellular vesicle miRNA with preeclampsia

Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease.

The placenta and adverse pregnancy outcomes – opening the black box?

Gestational protein restriction induces alterations in placental morphology and mitochondrial function in rats during late pregnancy

Levels of soluble fms-like tyrosine kinase one in first trimester and outcomes of pregnancy: a systematic review

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

Hypertensive Disorders of Pregnancy and Fetal Growth Restriction: Clinical Characteristics and Placental Lesions and Possible Preventive Nutritional Targets

Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications

Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels

Similar Documents

Placental OLAH Levels Are Altered in Fetal Growth Restriction, Preeclampsia and Models of Placental Dysfunction

Associations of maternal and placental extracellular vesicle miRNA with preeclampsia

Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease.

The placenta and adverse pregnancy outcomes – opening the black box?

Gestational protein restriction induces alterations in placental morphology and mitochondrial function in rats during late pregnancy

Levels of soluble fms-like tyrosine kinase one in first trimester and outcomes of pregnancy: a systematic review

Vitamin D receptor polymorphisms in hypertensive disorders of pregnancy

Hypertensive Disorders of Pregnancy and Fetal Growth Restriction: Clinical Characteristics and Placental Lesions and Possible Preventive Nutritional Targets

Significance of Sex Differences in ncRNAs Expression and Function in Pregnancy and Related Complications

Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels