NDLI: Immobilizing a single pybox ligand onto a library of solid supports

Content Provider	Springer Nature Link
Author	Cornejo, Alfonso Fraile, José M. García, José I. Gil, María J. Martínez Meri, Víctor Mayoral, José A.
Copyright Year	2003
Abstract	Chiral pyridinebis(oxazoline) (pybox) ligands can be efficiently immobilized onto silica through position 4 of the pyridine ring. The crucial intermediate in this strategy is 4-chloropybox, which is prepared in good yield from chelidamic acid. 4-Chloropybox reacts with p-hydroxybenzaldehyde and p-aminophenol to give two intermediates (pybox-CHO and pybox-NH$_{2}$) that allow to introduce the formyl and amino groups able to link to spacers with triethoxysilylgroups. The modified ligands and their ruthenium complexes are immobilized by grafting onto pre-formed silicas or, alternatively, the support is created by sol-gel synthesis using the functionalizedchiral ligand as a silica monomer. In this way it is possible to create a library where the variation involves the support rather than the catalyst. The aim of this approach is to study the influence of different parameters, such as the textural properties of the support and the immobilization method, on the functionalization and catalytic performance. Some of the immobilized complexes are compared as heterogeneous catalysts in the cyclopropanation reaction of styrene with ethyl diazoacetate.
Starting Page	93
Ending Page	105
Page Count	13
File Format	PDF
ISSN	13811991
Journal	Molecular Diversity
Volume Number	6
Issue Number	2
e-ISSN	1573501X
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2003-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Analytical Chemistry Organic Chemistry Polymer Sciences Pharmacy
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Medicine Drug Discovery Molecular Biology Physical and Theoretical Chemistry Information Systems Catalysis Inorganic Chemistry

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