NDLI: Comparative study of reductive amination reaction on 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid and its monomethoxy analog using the Multipin™ approach

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Comparative study of reductive amination reaction on 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid and its monomethoxy analog using the Multipin™ approach

Content Provider	Springer Nature Link
Author	Bui, Chinh T. Bray, Andrew M. Pham, Yen Campbell, Rhonda Ercole, Francesca Rasoul, Firas A. Joe Maeji, N.
Copyright Year	1998
Abstract	The 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid (Barany)linker and its monomethoxy analog were applied to theMultipin™ method of solid phase synthesis. Acomparative assessment of reductive amination and cleavage ofthese linkers under conditions of multiple synthesis indicatedthat both were applicable to a broad range of primary aminesincluding aniline and 4-nitroaniline. Apart from the greaterlability of the dimethoxy version under TFA cleavage, there wasno observable advantage of one linker over the other within thedescribed experiment.
Starting Page	155
Ending Page	163
Page Count	9
File Format	PDF
ISSN	13811991
Journal	Molecular Diversity
Volume Number	4
Issue Number	3
e-ISSN	1573501X
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1998-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Analytical Chemistry Organic Chemistry Polymer Sciences Pharmacy
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Medicine Drug Discovery Molecular Biology Physical and Theoretical Chemistry Information Systems Catalysis Inorganic Chemistry

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