NDLI: Molecular evolution of toxin genes in Elapidae snakes

Content Provider	Springer Nature Link
Author	Tamiya, Toru Fujimi, Takahiko J.
Copyright Year	2006
Abstract	The venom of the sea krait, Laticauda semifasciata, consists primarily of two toxic proteins, phospholipase A$_{2}$ (PLA$_{2}$) and a three-finger-structure toxin. We have cloned both toxic protein genes, including the upstream region. PLA$_{2}$ genes contain three types of inserted sequences: an AG-rich region, a chicken repeat 1-like long interspersed nucleotide element sequence and an intron II 3′ side repeat sequence. The molecular divergence of L. semifasciata PLA$_{2}$ genes was defined on the basis of the inserted sequences and their sequence homology. The length of intron I in the three-finger-structure toxin genes differs from species to species. The alignment analysis of intron I of the three-finger-structure toxin genes revealed that the intron I sequence of the ancestral gene comprised ten genetic regions. A hypothetical evolutionary process for the three-finger-structure toxin genes has also been developed.
Starting Page	529
Ending Page	543
Page Count	15
File Format	PDF
ISSN	13811991
Journal	Molecular Diversity
Volume Number	10
Issue Number	4
e-ISSN	1573501X
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2006-11-10
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Molecular evolution α-Neurotoxin gene Phospholipase A$_{2}$ gene Snake toxin genes Pharmacy Organic Chemistry Polymer Sciences Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Medicine Drug Discovery Molecular Biology Physical and Theoretical Chemistry Information Systems Catalysis Inorganic Chemistry

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