NDLI: Macrocycles rapidly produced by multiple multicomponent reactions including bifunctional building blocks (MiBs)

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Macrocycles rapidly produced by multiple multicomponent reactions including bifunctional building blocks (MiBs)

Content Provider	Springer Nature Link
Author	Wessjohann, Ludger A. Ruijter, Eelco
Copyright Year	2005
Abstract	Naturally occurring macrocycles often exhibit remarkable biological activities and, therefore, constitute an attractive starting point for diversity-oriented synthesis for lead discovery in drug development. Multicomponent reactions have been used for the introduction of chemical diversity in strategies towards macrocycle libraries, mostly by combinational synthesis of a linear precursor combined with a subsequent macrocyclization reaction. The Ugi reaction in particular may be used for the macrocyclization itself as well, and a library of natural product-like macrocycles can be constructed in a single step from simple precursors. The efficiency and versatility of both strategies is immense and is exemplarily illustrated by the construction of small libraries of cyclopeptide alkaloid derivatives and biaryl ether macrocycles. The syntheses of the latter compound group are examples of multiple multicomponent macrocyclizations including bifunctional building blocks (M$^{3}$iB$^{3}$ or MiB), of which the Ugi-MiBs and their variations are discussed in more detail.
Starting Page	159
Ending Page	169
Page Count	11
File Format	PDF
ISSN	13811991
Journal	Molecular Diversity
Volume Number	9
Issue Number	1-3
e-ISSN	1573501X
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2005-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	diversity-oriented synthesis macrocycles multicomponent reactions natural products Ugi-reaction Analytical Chemistry Organic Chemistry Polymer Sciences Pharmacy
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Medicine Drug Discovery Molecular Biology Physical and Theoretical Chemistry Information Systems Catalysis Inorganic Chemistry

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