NDLI: Lysine decarboxylase activity as a factor of fluoroquinolone resistance in Escherichia coli

Content Provider	Springer Nature Link
Author	Akhova, A. V. Tkachenko, A. G.
Copyright Year	2009
Abstract	Exposure of E. coli cells to sublethal concentrations of fluoroquinolones induced synthesis of lysine decarboxylase LdcC, which was previously considered to be a constitutive enzyme. Under these conditions, a key role in this process is played by RNA polymerase σ$^{ S }$ subunit (RpoS); its quantity increased substantially in the presence of antibiotics. Fluoroquinolones of the second and third generations had a more pronounced effect on rpoS expression and LdcC activity than the first-generation antibiotics. A direct correlation was shown between the level of cadaverine, the product of lysine decarboxylase reaction in E. coli cells, and their resistance to fluoroquinolones. An increase in endogenous cadaverine reduced effectiveness of the second and third-generation fluoroquinolones, but had no effect on antimicrobial activity of the first-generation antibiotics. This is in good agreement with the hydrophilic properties of antibiotics of different generations and, consequently, with different mechanisms of their penetration into bacterial cells.
Starting Page	575
Ending Page	579
Page Count	5
File Format	PDF
ISSN	00262617
Journal	Microbiology
Volume Number	78
Issue Number	5
e-ISSN	16083237
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2009-10-11
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	fluoroquinolones cadaverine polyamines antibiotic resistance lysine decarboxylase LdcC rpoS Medical Microbiology Microbiology
Content Type	Text
Resource Type	Article
Subject	Microbiology Applied Microbiology and Biotechnology

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