NDLI: Inhibition of acetylcholinesterase activity in brain and behavioral analysis in adult rats after chronic administration of fenproporex

Content Provider	Springer Nature Link
Author	Rezin, Gislaine T. Scaini, Giselli Ferreira, Gabriela K. Cardoso, Mariane R. Gonçalves, Cinara L. Constanti, Larissa S. Deroza, Pedro F. Ghedim, Fernando V. Valvassori, Samira S. Resende, Wilson R. Quevedo, João Zug, Alexandra I. Streck, Emilio L.
Copyright Year	2012
Abstract	Fenproporex is an amphetamine-based anorectic and it is rapidly converted in vivo into amphetamine. It elevates the levels of extracellular dopamine in the brain. Acetylcholinesterase is a regulatory enzyme which is involved in cholinergic synapses and may indirectly modulate the release of dopamine. Thus, we investigated whether the effects of chronic administration of fenproporex in adult rats alters acquisition and retention of avoidance memory and acetylcholinesterase activity. Adult male Wistar rats received repeated (14 days) intraperitoneal injection of vehicle or fenproporex (6.25, 12.5 or 25 mg/kg i.p.). For behavioral assessment, animals were submitted to inhibitory avoidance (IA) tasks and continuous multiple trials step-down inhibitory avoidance (CMIA). Acetylcholinesterase activity was measured in the prefrontal cortex, hippocampus, hypothalamus and striatum. The administration of fenproporex (6.25, 12.5 and 25 mg/kg) did not induce impairment in short and long-term IA or CMIA retention memory in rats. In addition, longer periods of exposure to fenproporex administration decreased acetylcholinesterase activity in prefrontal cortex and striatum of rats, but no alteration was verified in the hippocampus and hypothalamus. In conclusion, the present study showed that chronic fenproporex administration decreased acetylcholinesterase activity in the rat brain. However, longer periods of exposure to fenproporex did not produce impairment in short and long-term IA or CMIA retention memory in rats.
Starting Page	453
Ending Page	458
Page Count	6
File Format	PDF
ISSN	08857490
Journal	Metabolic Brain Disease
Volume Number	27
Issue Number	4
e-ISSN	15737365
Language	English
Publisher	Springer US
Publisher Date	2012-07-27
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Acetylcholinesterase Fenproporex Behavioral Memory Biochemistry Oncology Metabolic Diseases Neurosciences Neurology
Content Type	Text
Resource Type	Article
Subject	Biochemistry Neurology (clinical) Cellular and Molecular Neuroscience

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