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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zheng, Hong Lin, Qiuting Wang, Dan Xu, Pengtao Zhao, Liangcai Hu, Wenyi Bai, Guanghui Yan, Zhihan Gao, Hongchang |
| Copyright Year | 2017 |
| Abstract | Diabetes mellitus (DM) can result in cognitive dysfunction, but its potential metabolic mechanisms remain unclear. In the present study, we analyzed the metabolite profiling in eight different brain regions of the normal rats and the streptozotocin (STZ)-induced diabetic rats accompanied by cognitive dysfunction using a $^{1}$H NMR-based metabolomic approach. A mixed linear model analysis was performed to assess the effects of DM, brain region and their interaction on metabolic changes. We found that different brain regions in rats displayed significant metabolic differences. In addition, the hippocampus was more susceptible to DM compared with other brain regions in rats. More interestingly, significant interaction effects of DM and brain region were observed on alanine, creatine/creatine-phosphate, lactate, succinate, aspartate, glutamate, glutamine, γ-aminobutyric acid, glycine, choline, N-acetylaspartate, myo-inositol and taurine. Based on metabolic pathway analysis, we speculate that cognitive dysfunction in the STZ-induced diabetic rats may be associated with brain region-specific metabolic alterations involving energy metabolism, neurotransmitters, membrane metabolism and osmoregulation. |
| Starting Page | 585 |
| Ending Page | 593 |
| Page Count | 9 |
| File Format | |
| ISSN | 08857490 |
| Journal | Metabolic Brain Disease |
| Volume Number | 32 |
| Issue Number | 2 |
| e-ISSN | 15737365 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2017-01-09 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Brain metabolism Cognitive decline Diabetes mellitus Hippocampus Neurotransmitter Neurosciences Neurology Metabolic Diseases Biochemistry Oncology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Neurology (clinical) Cellular and Molecular Neuroscience |
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