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| Content Provider | Springer Nature Link |
|---|---|
| Author | Song, Jin Ning Chen, Hu Zhang, Ming Zhao, Yong Lin Ma, Xu Dong |
| Copyright Year | 2012 |
| Abstract | Regional cerebral blood flow (rCBF) in the cerebral metabolism and energy metabolism measurements can be used to assess blood flow of brain cells and to detect cell activity. Changes of rCBF in the cerebral microcirculation and energy metabolism were determined in an experimental model of subarachnoid hemorrhage (SAH) model in 56 large-eared Japanese rabbits about 12 to 16-month old. Laser Doppler flowmetry was used to detect the blood supply to brain cells. Internal carotid artery and vein blood samples were used for duplicate blood gas analysis to assess the energy metabolism of brain cells. Cerebral blood flow (CBF) was detected by single photon emission computed tomography (SPECT) perfusion imaging using Tc-99m ethyl cysteinate dimer (Tc-99m ECD) as an imaging reagent. The percentage of injected dose per gram of brain tissue was calculated and analyzed. There were positive correlations between the percentage of radionuclide injected per gram of brain tissue and rCBF supply and cerebral metabolic rate for oxygen (P < 0.05). However, there was a negative correlation between radioactivity counts per unit volume detected on the SPECT rheoencephalogram and lactic acid concentration in the homolateral internal carotid artery and vein. In summary, this study found abnormal CBF in metabolism and utilization of brain cells after SAH, and also found that deterioration of energy metabolism of brain cells played a significant role in the development of SAH. There are matched reductions in CBF and metabolism. Thus, SPECT imaging could be used as a noninvasive method to detect CBF. |
| Starting Page | 33 |
| Ending Page | 43 |
| Page Count | 11 |
| File Format | |
| ISSN | 08857490 |
| Journal | Metabolic Brain Disease |
| Volume Number | 28 |
| Issue Number | 1 |
| e-ISSN | 15737365 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2012-12-12 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Subarachnoid hemorrhage Microcirculation Energy metabolism Cerebral blood flow Single-photon emission computed tomography Neurosciences Neurology Metabolic Diseases Biochemistry Oncology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Neurology (clinical) Cellular and Molecular Neuroscience |
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