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| Content Provider | Springer Nature Link |
|---|---|
| Author | Stracciari, Andrea Mattarozzi, Katia D’Alessandro, Roberto Baldin, Elisa Guari, Maria |
| Copyright Year | 2008 |
| Abstract | CNS involvement is frequent in patients with chronic liver disease, resulting in overt or subclinical (“minimal”) encephalopathy. Occasionally, patients liver cirrhosis may develop a progressive encephalopathy known as chronic acquired hepatocerebral degeneration (CAHD), presenting with neuropsychiatric changes and movement disorders. In patients affected by CAHD cognitive dysfunction is the rule, but to date this aspect has not been systematically studied. Our aim was to characterize the neuropsychological profile of cognitive impairment associated with CAHD. Eight patients with CAHD received extensive neuropsychological assessment, far from episodes of acute liver decompensation. Their cognitive performances were compared with those of 8 patients with cirrhosis free from CAHD or overt hepatic encephalopathy (HE) and with those of 8 healthy controls matched for age, sex and educational level. Patients with CAHD revealed a significant impairment of visuo-spatial attention compared to healthy controls, and a lower performance on a single task of visual search and sequencing when compared to cirrhotics without CAHD. Our findings support the hypothesis of a linear decline in attentional performances of patients with chronic liver disease, starting from cognitively intact patients, moving toward patients with minimal HE, and finally progressing to those with overt HE and CAHD. |
| Starting Page | 155 |
| Ending Page | 160 |
| Page Count | 6 |
| File Format | |
| ISSN | 08857490 |
| Journal | Metabolic Brain Disease |
| Volume Number | 23 |
| Issue Number | 2 |
| e-ISSN | 15737365 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2008-04-24 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cognition Hepatocerebral degeneration Liver cirrhosis Movement disorders Oncology Biochemistry Neurology Neurosciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Neurology (clinical) Cellular and Molecular Neuroscience |
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