NDLI: Evaluation of respiratory chain activity in lymphocytes of patients with Alzheimer disease

Content Provider	Springer Nature Link
Author	Feldhaus, Pollyana Fraga, Daiane B. Ghedim, Fernando V. Luca, Renata D. Bruna, Thiago D. Heluany, Matheus Matos, Maria Paula Ferreira, Gabriela K. Jeremias, Isabela C. Heluany, Claudia Streck, Emilio L. Zug, Alexandra I.
Copyright Year	2011
Abstract	Alzheimer disease (AD) is a progressive neurodegenerative disease associated with cognitive impairment in multiple domains, such as memory and executive functions. Studies reveal damage in the electron transport chain of patients with AD, suggesting that this mitochondrial dysfunction plays an important role in the pathophysiology of the disease. Blood samples were taken from patients with AD (n = 20) and older subjects without dementia (n = 40) to evaluate the activity of complexes I, II, II–III, and IV of the mitochondrial respiratory chain in isolated lymphocytes. Results from the patient and control groups were compared. The activity of complexes II and IV was increased among patients compared to the control group. No significant difference was observed between controls who were not using psychotropic medication and patients. Our findings point out a mechanism of cellular compensation in which the mitochondrial respiratory chain requires an increase in electron transport to supply the energy needed for cellular functioning. Additional studies are needed to better clarify the mechanisms involved in the mitochondrial dynamics of AD.
Starting Page	229
Ending Page	236
Page Count	8
File Format	PDF
ISSN	08857490
Journal	Metabolic Brain Disease
Volume Number	26
Issue Number	3
e-ISSN	15737365
Language	English
Publisher	Springer US
Publisher Date	2011-07-26
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Alzheimer disease Mitochondria Electron transport chain Neurosciences Oncology Biochemistry Metabolic Diseases Neurology
Content Type	Text
Resource Type	Article
Subject	Biochemistry Neurology (clinical) Cellular and Molecular Neuroscience

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