NDLI: Change in the telomere length distribution with age in the Japanese population

Content Provider	Springer Nature Link
Author	Guan, Jing Zhi Maeda, Toyoki Suga, Masahiro Oyama, Jun ichi Higuchi, Yoshihiro Maki, Naoki
Copyright Year	2007
Abstract	Telomeres play a role in cellular aging and they may also contribute to the genetic basis of human aging and longevity. A gradual loss of the telomeric repeat sequences has been reported in adult tissue specimens. This study determined the percentage of telomere restriction fragment in various molecular-sized regions in addition to measuring the average telomere length. Mean telomere restriction fragment (TRF) length was determined by Southern blot analysis using a longer telomeric repeat probe with higher sensitivity. A significant decrease in longer telomere fragments and a quick increase in the shortest fragments were observed, especially in male subjects. There was a tendency that the age-adjusted telomere length was longer in females than that observed in males, while males lose the telomeric sequence faster than females. These data indicated that the percentage of longer telomeres fragments decreased, while the shortest fragments increased quickly with age. In addition, the longest telomere fragments decreased and the short fragments increased with a relatively stable frequency with age. There was also a significant difference in the longest telomere fragment percentage between males and female in their 40s and 50s, whereas no difference was observed in the mean TRF length. Interestingly, the changing rate of the longest and the shortest range group of TRF percentage associated with aging seemed quite different between before and after 50-year old with a gender-related contrast. This contrast implies a drastic change around the age of 50 of unknown factors that affect telomere attrition.
Starting Page	353
Ending Page	360
Page Count	8
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	304
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Springer US
Publisher Date	2007-06-27
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Telomere Age Japanese Gender Cardiology Oncology Medical Biochemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Changes in telomere length distribution in low-dose X-ray-irradiated human umbilical vein endothelial cells

Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening

Change in the telomere length distribution with age in the Japanese population

Angiotensin II type 1 receptor gene polymorphism and telomere shortening in essential hypertension

The induction of cellular senescence in dental follicle cells inhibits the osteogenic differentiation

FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction

Altered expression of genes associated with telomere maintenance and cell function of human vascular endothelial cell at elevated temperature

Nuclease susceptibility of the rat liver satellite DNA-containing chromatin decreases with age

In vivo detection of nitric oxide distribution in mice

Change in the telomere length distribution with age in the Japanese population

Similar Documents

Changes in telomere length distribution in low-dose X-ray-irradiated human umbilical vein endothelial cells

Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening

Change in the telomere length distribution with age in the Japanese population

Angiotensin II type 1 receptor gene polymorphism and telomere shortening in essential hypertension

The induction of cellular senescence in dental follicle cells inhibits the osteogenic differentiation

FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction

Altered expression of genes associated with telomere maintenance and cell function of human vascular endothelial cell at elevated temperature

Nuclease susceptibility of the rat liver satellite DNA-containing chromatin decreases with age

In vivo detection of nitric oxide distribution in mice

Change in the telomere length distribution with age in the Japanese population