NDLI: Effect of mercuric chloride on various hydroxyproline fractions in rat serum

Content Provider	Springer Nature Link
Author	Siddiqi, N. J. Alhomida, A. S.
Copyright Year	2005
Abstract	Mercuric chloride (HgCl$_{2}$) disturbs the collagen metabolism in the body which is reflected by altered hydroxyproline fractions in the serum. The aim of the present investigation was to study the effect of HgCl$_{2}$ treatment on various hydroxyproline (Hyp) fractions in rat serum and the effect of 2,3-dimercapto-1-propane sulfonic acid (DMPS) treatment on serum Hyp fractions in HgCl$_{2}$ treated rats. Other parameters studied included body weight, food intake, water intake and kidney weight. Doses of HgCl$_{2}$ used were 0.1, 0.5, 1.0, 2.0, 3.0 mg/kg body weight and that of DMPS was 100 mg DMPS/kg body weight. All the doses of HgCl$_{2}$ used caused significant (p < 0.01) alterations in free, peptide-bound and protein-bound Hyp in the serum when compared with control rats but a dose of 2 mg/kg body weight caused significant (p < 0.001) alteration even in the total serum Hyp when compared to control rats. Administration of DMPS prior HgCl$_{2}$ treatment of rats sacrificed 24 h after the treatment caused a significant decrease of 52% (p < 0.01) in free Hyp when compared to similar HgCl$_{2}$ treated rats. DMPS treatment with HgCl$_{2}$ also caused an increase of 61% (p < 0.001) and 114% (p < 0. 001) in peptide- and protein-bound Hyp respectively, when compared to HgCl$_{2}$ treated rats sacrificed 24 h after mercuric chloride and DMPS treatment. Administration of DMPS followed by HgCl$_{2}$ to rats which were sacrificed 48 h later caused no significant change in the total and free Hyp when compared to HgCl$_{2}$ treated rats which were sacrificed 48 h after the treatment. But there was a significant decrease of 40% (p < 0.001) in peptide-bound Hyp and an increase in of 77% (p < 0.001) in protein-bound Hyp when compared to HgCl$_{2}$ treated rats sacrificed 48 h after the treatment. The present study shows that HgCl$_{2}$ treatment caused significant alterations in serum Hyp fractions reflecting disturbed composition of connective tissues which were not reversed by DMPS treatment. (Mol Cell Biochem 271: 159–165, 2005)
Starting Page	159
Ending Page	165
Page Count	7
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	271
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2005-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	mercuric chloride 2,3-dimercapto-1-propane sulfonic acid hydroxyproline collagen Cardiology Medical Biochemistry Oncology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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