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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zhang, Mei Luo Elkassem, Samer Davidoff, Allen W. Saito, Kaoru ter Keurs, Henk E.D.J. |
| Copyright Year | 2003 |
| Abstract | Hypertrophy and heart failure following a myocardial infarction in rodents are accompanied by a switch of myosin isoforms from V$_{1}$ to V$_{3}$. The angiotensin II receptor blocker, Losartan, has been demonstrated to improve cardiac function and long-term survival after myocardial infarction. In this study we have investigated whether chronic Losartan treatment affects myosin isoform composition in the hearts of rats following a myocardial infarction. Rats were subjected to coronary artery ligation and received either Losartan (1 g/L) in the drinking water or water only. Four months after myocardial infarction, rats were classified as having either congestive heart failure (cMI) or uncomplicated myocardial infarction (uMI) based on their lung weight to body weight ratio (LW/BW). Compared with sham operated rats, uMI rats showed a 68.5% increase in the relative contribution of V$_{3}$ and a 33.7% decrease in the relative contribution of V$_{1}$ (p < 0.05). Untreated cMI showed 39.7% more V$_{3}$ and 38.2% less V$_{1}$ when compared with untreated uMI (p < 0.05). Losartan treatment after myocardial infarction reduced the incidence of cMI from 30.4 to 4.5% and scar size from 1.52 ± 0.07 to 0.94 ± 0.11 cm$^{2}$ respectively. The percentage of V$_{1}$ in Losartan treated uMI (LuMI) was 25.2% higher than the percentage of V$_{1}$ in untreated uMI (p < 0.05), whereas the percentage of V$_{3}$ in LuMI was 24.2% lower than that in untreated uMI (p < 0.05). A positive correlation of V$_{3}$ myosin and scar area was observed. Our study suggests that expression of V$_{3}$ myosin in the left ventricle is associated with scar size and the progress of hemodynamic changes after myocardial infarction. Losartan treatment reduces scar size and wall stress of the heart after the infarct, and therefore inhibits the signals shifting myosin isoform expression from V$_{1}$ to V$_{3}$ after a myocardial infarction. |
| Starting Page | 111 |
| Ending Page | 117 |
| Page Count | 7 |
| File Format | |
| ISSN | 03008177 |
| Journal | Molecular and Cellular Biochemistry |
| Volume Number | 251 |
| Issue Number | 1-2 |
| e-ISSN | 15734919 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2003-01-01 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cardiology Medical Biochemistry Oncology Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Clinical Biochemistry Molecular Biology |
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