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  1. Molecular and Cellular Biochemistry
  2. Molecular and Cellular Biochemistry : Volume 356
  3. Molecular and Cellular Biochemistry : Volume 356, Issue 1-2, October 2011
  4. Design and synthesis of CK2 inhibitors
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Molecular and Cellular Biochemistry : Volume 430
Molecular and Cellular Biochemistry : Volume 429
Molecular and Cellular Biochemistry : Volume 428
Molecular and Cellular Biochemistry : Volume 427
Molecular and Cellular Biochemistry : Volume 426
Molecular and Cellular Biochemistry : Volume 425
Molecular and Cellular Biochemistry : Volume 424
Molecular and Cellular Biochemistry : Volume 423
Molecular and Cellular Biochemistry : Volume 422
Molecular and Cellular Biochemistry : Volume 421
Molecular and Cellular Biochemistry : Volume 420
Molecular and Cellular Biochemistry : Volume 419
Molecular and Cellular Biochemistry : Volume 418
Molecular and Cellular Biochemistry : Volume 417
Molecular and Cellular Biochemistry : Volume 416
Molecular and Cellular Biochemistry : Volume 415
Molecular and Cellular Biochemistry : Volume 414
Molecular and Cellular Biochemistry : Volume 413
Molecular and Cellular Biochemistry : Volume 412
Molecular and Cellular Biochemistry : Volume 411
Molecular and Cellular Biochemistry : Volume 410
Molecular and Cellular Biochemistry : Volume 409
Molecular and Cellular Biochemistry : Volume 408
Molecular and Cellular Biochemistry : Volume 407
Molecular and Cellular Biochemistry : Volume 406
Molecular and Cellular Biochemistry : Volume 405
Molecular and Cellular Biochemistry : Volume 404
Molecular and Cellular Biochemistry : Volume 403
Molecular and Cellular Biochemistry : Volume 402
Molecular and Cellular Biochemistry : Volume 401
Molecular and Cellular Biochemistry : Volume 400
Molecular and Cellular Biochemistry : Volume 399
Molecular and Cellular Biochemistry : Volume 398
Molecular and Cellular Biochemistry : Volume 397
Molecular and Cellular Biochemistry : Volume 396
Molecular and Cellular Biochemistry : Volume 395
Molecular and Cellular Biochemistry : Volume 394
Molecular and Cellular Biochemistry : Volume 393
Molecular and Cellular Biochemistry : Volume 392
Molecular and Cellular Biochemistry : Volume 391
Molecular and Cellular Biochemistry : Volume 390
Molecular and Cellular Biochemistry : Volume 389
Molecular and Cellular Biochemistry : Volume 388
Molecular and Cellular Biochemistry : Volume 387
Molecular and Cellular Biochemistry : Volume 386
Molecular and Cellular Biochemistry : Volume 385
Molecular and Cellular Biochemistry : Volume 384
Molecular and Cellular Biochemistry : Volume 383
Molecular and Cellular Biochemistry : Volume 382
Molecular and Cellular Biochemistry : Volume 381
Molecular and Cellular Biochemistry : Volume 380
Molecular and Cellular Biochemistry : Volume 379
Molecular and Cellular Biochemistry : Volume 378
Molecular and Cellular Biochemistry : Volume 377
Molecular and Cellular Biochemistry : Volume 376
Molecular and Cellular Biochemistry : Volume 375
Molecular and Cellular Biochemistry : Volume 374
Molecular and Cellular Biochemistry : Volume 373
Molecular and Cellular Biochemistry : Volume 372
Molecular and Cellular Biochemistry : Volume 371
Molecular and Cellular Biochemistry : Volume 370
Molecular and Cellular Biochemistry : Volume 369
Molecular and Cellular Biochemistry : Volume 368
Molecular and Cellular Biochemistry : Volume 367
Molecular and Cellular Biochemistry : Volume 366
Molecular and Cellular Biochemistry : Volume 365
Molecular and Cellular Biochemistry : Volume 364
Molecular and Cellular Biochemistry : Volume 363
Molecular and Cellular Biochemistry : Volume 362
Molecular and Cellular Biochemistry : Volume 361
Molecular and Cellular Biochemistry : Volume 360
Molecular and Cellular Biochemistry : Volume 359
Molecular and Cellular Biochemistry : Volume 358
Molecular and Cellular Biochemistry : Volume 357
Molecular and Cellular Biochemistry : Volume 356
Molecular and Cellular Biochemistry : Volume 356, Issue 1-2, October 2011
Protein kinase CK2: a catalyst for biology, medicine and structural biochemistry
Protein kinase CK2 accumulation in “oncophilic” cells: causes and effects
Regulation of epithelial to mesenchymal transition: CK2β on stage
Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α′ subunits reduces orthotopic xenograft prostate tumors in mice
Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer
CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research
On CK2 regulation of chronic lymphocytic leukemia cell viability
Enzymatic activity with an incomplete catalytic spine: insights from a comparative structural analysis of human CK2α and its paralogous isoform CK2α′
Structural and functional determinants of protein kinase CK2α: facts and open questions
Structure–function analysis of the beta regulatory subunit of protein kinase CK2 by targeting embryonic stem cell
Identification of novel CK2 inhibitors with a benzofuran scaffold by novel non-radiometric in vitro assays
Design and synthesis of CK2 inhibitors
A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase
Structure-based discovery of novel flavonol inhibitors of human protein kinase CK2
Multisite-directed inhibitors of protein kinase CK2: new challenges
Interactions between subunits of protein kinase CK2 and their protein substrates influences its sensitivity to specific inhibitors
CK2 functionally interacts with AKT/PKB to promote the β-catenin-dependent expression of survivin and enhance cell survival
Induction and activation of the p53 pathway: a role for the protein kinase CK2?
Lack of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is accompanied by increased CK2α′ levels
Role of polyamines in determining the cellular response to chemotherapeutic agents: modulation of protein kinase CK2 expression and activity
Regulation of caspase pathways by protein kinase CK2: identification of proteins with overlapping CK2 and caspase consensus motifs
Predominance of CK2α over CK2α′ in the mammalian brain
Down-regulation of CK2 activity results in a decrease in the level of cdc25C phosphatase in different prostate cancer cell lines
Adiponectin receptor 1 interacts with both subunits of protein kinase CK2
Stimulation of CK2-dependent Grp94 phosphorylation by the nuclear localization signal peptide
Ikaros, CK2 kinase, and the road to leukemia
CK2α is essential for embryonic morphogenesis
New insights into the Orange domain of E(spl)-M8, and the roles of the C-terminal domain in autoinhibition and Groucho recruitment
Developmental and growth defects in mice with combined deficiency of CK2 catalytic genes
About the role of CK2 in plant signal transduction
Phosphorylation of maize eukaryotic translation initiation factor on Ser2 by catalytic subunit CK2
The p23 co-chaperone protein is a novel substrate of CK2 in Arabidopsis
Specific characteristics of CK2β regulatory subunits in plants
Cloning and purification of protein kinase CK2 recombinant alpha and beta subunits from the Mediterranean fly Ceratitis capitata
Nutritional modulation of CK2 in Saccharomyces cerevisiae: regulating the activity of a constitutive enzyme
Molecular and Cellular Biochemistry : Volume 355
Molecular and Cellular Biochemistry : Volume 354
Molecular and Cellular Biochemistry : Volume 353
Molecular and Cellular Biochemistry : Volume 352
Molecular and Cellular Biochemistry : Volume 351
Molecular and Cellular Biochemistry : Volume 350
Molecular and Cellular Biochemistry : Volume 349
Molecular and Cellular Biochemistry : Volume 348
Molecular and Cellular Biochemistry : Volume 347
Molecular and Cellular Biochemistry : Volume 346
Molecular and Cellular Biochemistry : Volume 345
Molecular and Cellular Biochemistry : Volume 344
Molecular and Cellular Biochemistry : Volume 343
Molecular and Cellular Biochemistry : Volume 342
Molecular and Cellular Biochemistry : Volume 341
Molecular and Cellular Biochemistry : Volume 340
Molecular and Cellular Biochemistry : Volume 339
Molecular and Cellular Biochemistry : Volume 338
Molecular and Cellular Biochemistry : Volume 337
Molecular and Cellular Biochemistry : Volume 336
Molecular and Cellular Biochemistry : Volume 335
Molecular and Cellular Biochemistry : Volume 334
Molecular and Cellular Biochemistry : Volume 333
Molecular and Cellular Biochemistry : Volume 332
Molecular and Cellular Biochemistry : Volume 331
Molecular and Cellular Biochemistry : Volume 330
Molecular and Cellular Biochemistry : Volume 329
Molecular and Cellular Biochemistry : Volume 328
Molecular and Cellular Biochemistry : Volume 327
Molecular and Cellular Biochemistry : Volume 326
Molecular and Cellular Biochemistry : Volume 325
Molecular and Cellular Biochemistry : Volume 324
Molecular and Cellular Biochemistry : Volume 323
Molecular and Cellular Biochemistry : Volume 322
Molecular and Cellular Biochemistry : Volume 321
Molecular and Cellular Biochemistry : Volume 320
Molecular and Cellular Biochemistry : Volume 319
Molecular and Cellular Biochemistry : Volume 318
Molecular and Cellular Biochemistry : Volume 317
Molecular and Cellular Biochemistry : Volume 316
Molecular and Cellular Biochemistry : Volume 315
Molecular and Cellular Biochemistry : Volume 314
Molecular and Cellular Biochemistry : Volume 313
Molecular and Cellular Biochemistry : Volume 312
Molecular and Cellular Biochemistry : Volume 311
Molecular and Cellular Biochemistry : Volume 310
Molecular and Cellular Biochemistry : Volume 309
Molecular and Cellular Biochemistry : Volume 308
Molecular and Cellular Biochemistry : Volume 307
Molecular and Cellular Biochemistry : Volume 306
Molecular and Cellular Biochemistry : Volume 305
Molecular and Cellular Biochemistry : Volume 304
Molecular and Cellular Biochemistry : Volume 303
Molecular and Cellular Biochemistry : Volume 302
Molecular and Cellular Biochemistry : Volume 301
Molecular and Cellular Biochemistry : Volume 300
Molecular and Cellular Biochemistry : Volume 299
Molecular and Cellular Biochemistry : Volume 298
Molecular and Cellular Biochemistry : Volume 297
Molecular and Cellular Biochemistry : Volume 296
Molecular and Cellular Biochemistry : Volume 295
Molecular and Cellular Biochemistry : Volume 294
Molecular and Cellular Biochemistry : Volume 293
Molecular and Cellular Biochemistry : Volume 292
Molecular and Cellular Biochemistry : Volume 291
Molecular and Cellular Biochemistry : Volume 290
Molecular and Cellular Biochemistry : Volume 289
Molecular and Cellular Biochemistry : Volume 288
Molecular and Cellular Biochemistry : Volume 287
Molecular and Cellular Biochemistry : Volume 286
Molecular and Cellular Biochemistry : Volume 285
Molecular and Cellular Biochemistry : Volume 284
Molecular and Cellular Biochemistry : Volume 283
Molecular and Cellular Biochemistry : Volume 282
Molecular and Cellular Biochemistry : Volume 281
Molecular and Cellular Biochemistry : Volume 280
Molecular and Cellular Biochemistry : Volume 279
Molecular and Cellular Biochemistry : Volume 278
Molecular and Cellular Biochemistry : Volume 277
Molecular and Cellular Biochemistry : Volume 276
Molecular and Cellular Biochemistry : Volume 275
Molecular and Cellular Biochemistry : Volume 274
Molecular and Cellular Biochemistry : Volume 273
Molecular and Cellular Biochemistry : Volume 272
Molecular and Cellular Biochemistry : Volume 271
Molecular and Cellular Biochemistry : Volume 270
Molecular and Cellular Biochemistry : Volume 269
Molecular and Cellular Biochemistry : Volume 268
Molecular and Cellular Biochemistry : Volume 267
Molecular and Cellular Biochemistry : Volume 266
Molecular and Cellular Biochemistry : Volume 265
Molecular and Cellular Biochemistry : Volume 264
Molecular and Cellular Biochemistry : Volume 263
Molecular and Cellular Biochemistry : Volume 262
Molecular and Cellular Biochemistry : Volume 261
Molecular and Cellular Biochemistry : Volume 260
Molecular and Cellular Biochemistry : Volume 259
Molecular and Cellular Biochemistry : Volume 258
Molecular and Cellular Biochemistry : Volume 256
Molecular and Cellular Biochemistry : Volume 255
Molecular and Cellular Biochemistry : Volume 254
Molecular and Cellular Biochemistry : Volume 253
Molecular and Cellular Biochemistry : Volume 252
Molecular and Cellular Biochemistry : Volume 251
Molecular and Cellular Biochemistry : Volume 250
Molecular and Cellular Biochemistry : Volume 249
Molecular and Cellular Biochemistry : Volume 248
Molecular and Cellular Biochemistry : Volume 247
Molecular and Cellular Biochemistry : Volume 246
Molecular and Cellular Biochemistry : Volume 245
Molecular and Cellular Biochemistry : Volume 244
Molecular and Cellular Biochemistry : Volume 243
Molecular and Cellular Biochemistry : Volume 242
Molecular and Cellular Biochemistry : Volume 241
Molecular and Cellular Biochemistry : Volume 240
Molecular and Cellular Biochemistry : Volume 239
Molecular and Cellular Biochemistry : Volume 238
Molecular and Cellular Biochemistry : Volume 237
Molecular and Cellular Biochemistry : Volume 236
Molecular and Cellular Biochemistry : Volume 234
Molecular and Cellular Biochemistry : Volume 233
Molecular and Cellular Biochemistry : Volume 232
Molecular and Cellular Biochemistry : Volume 231
Molecular and Cellular Biochemistry : Volume 230
Molecular and Cellular Biochemistry : Volume 229
Molecular and Cellular Biochemistry : Volume 228
Molecular and Cellular Biochemistry : Volume 227
Molecular and Cellular Biochemistry : Volume 226
Molecular and Cellular Biochemistry : Volume 225
Molecular and Cellular Biochemistry : Volume 224
Molecular and Cellular Biochemistry : Volume 223
Molecular and Cellular Biochemistry : Volume 222
Molecular and Cellular Biochemistry : Volume 221
Molecular and Cellular Biochemistry : Volume 220
Molecular and Cellular Biochemistry : Volume 219
Molecular and Cellular Biochemistry : Volume 218
Molecular and Cellular Biochemistry : Volume 217
Molecular and Cellular Biochemistry : Volume 216
Molecular and Cellular Biochemistry : Volume 215
Molecular and Cellular Biochemistry : Volume 214
Molecular and Cellular Biochemistry : Volume 213
Molecular and Cellular Biochemistry : Volume 212
Molecular and Cellular Biochemistry : Volume 211
Molecular and Cellular Biochemistry : Volume 210
Molecular and Cellular Biochemistry : Volume 209
Molecular and Cellular Biochemistry : Volume 208
Molecular and Cellular Biochemistry : Volume 207
Molecular and Cellular Biochemistry : Volume 206
Molecular and Cellular Biochemistry : Volume 205
Molecular and Cellular Biochemistry : Volume 204
Molecular and Cellular Biochemistry : Volume 203
Molecular and Cellular Biochemistry : Volume 202
Molecular and Cellular Biochemistry : Volume 201
Molecular and Cellular Biochemistry : Volume 200
Molecular and Cellular Biochemistry : Volume 199
Molecular and Cellular Biochemistry : Volume 198
Molecular and Cellular Biochemistry : Volume 197
Molecular and Cellular Biochemistry : Volume 196
Molecular and Cellular Biochemistry : Volume 195
Molecular and Cellular Biochemistry : Volume 194
Molecular and Cellular Biochemistry : Volume 193
Molecular and Cellular Biochemistry : Volume 192
Molecular and Cellular Biochemistry : Volume 191
Molecular and Cellular Biochemistry : Volume 190
Molecular and Cellular Biochemistry : Volume 189
Molecular and Cellular Biochemistry : Volume 188
Molecular and Cellular Biochemistry : Volume 187
Molecular and Cellular Biochemistry : Volume 186
Molecular and Cellular Biochemistry : Volume 185
Molecular and Cellular Biochemistry : Volume 184
Molecular and Cellular Biochemistry : Volume 183
Molecular and Cellular Biochemistry : Volume 182
Molecular and Cellular Biochemistry : Volume 181
Molecular and Cellular Biochemistry : Volume 180
Molecular and Cellular Biochemistry : Volume 179
Molecular and Cellular Biochemistry : Volume 178
Molecular and Cellular Biochemistry : Volume 177
Molecular and Cellular Biochemistry : Volume 176
Molecular and Cellular Biochemistry : Volume 175
Molecular and Cellular Biochemistry : Volume 174
Molecular and Cellular Biochemistry : Volume 173
Molecular and Cellular Biochemistry : Volume 172
Molecular and Cellular Biochemistry : Volume 171
Molecular and Cellular Biochemistry : Volume 170
Molecular and Cellular Biochemistry : Volume 169
Molecular and Cellular Biochemistry : Volume 168
Molecular and Cellular Biochemistry : Volume 167
Molecular and Cellular Biochemistry : Volume 166

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New inhibitors of protein kinase CK2, analogues of benzimidazole and benzotriazole

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Benzimidazole inhibitors of protein kinase CK2 potently inhibit the activity of atypical protein kinase Rio1

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Design and synthesis of CK2 inhibitors

Content Provider Springer Nature Link
Author Makowska, Małgorzata Łukowska Chojnacka, Edyta Wińska, Patrycja Kuś, Agnieszka Bilińska Chomik, Aleksandra Bretner, Maria
Copyright Year 2011
Abstract A series of new polybrominated benzimidazoles and benzotriazoles has been synthesized and their influence on the activity of protein kinase CK2 was evaluated. It was revealed that the most active inhibitors are those with methyl or ethyl substituent at benzene ring, namely 5,6,7-tribromo-4-methyl-1H-benzotriazole (38, IC$_{50}$ 0.51 μM) and 5,6,7-tribromo-4-ethyl-1H-benzotriazole (40, IC$_{50}$ 0.16 μM). The derivatives with large aromatic or heterocyclic substituents connected to benzimidazole or benzotriazole scaffold appeared to be less potent inhibitors.
Starting Page 91
Ending Page 96
Page Count 6
File Format PDF
ISSN 03008177
Journal Molecular and Cellular Biochemistry
Volume Number 356
Issue Number 1-2
e-ISSN 15734919
Language English
Publisher Springer US
Publisher Date 2011-07-13
Publisher Place Boston
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword 4,5,6,7-Tetrabromo-1H-benzotriazole derivatives 4,5,6,7-Tetrabromo-1H-benzimidazole derivatives CK2 kinase inhibitors Oncology Biochemistry Cardiology Medical Biochemistry
Content Type Text
Resource Type Article
Subject Cell Biology Medicine Clinical Biochemistry Molecular Biology
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