NDLI: Overexpression of SYF2 correlates with enhanced cell growth and poor prognosis in human hepatocellular carcinoma

Content Provider	Springer Nature Link
Author	Zhang, Shusen Shi, Weidong Chen, Yuyan Xu, Zhiwei Zhu, Jia Zhang, Tingting Huang, Wei Ni, Runzhou Lu, Cuihua Zhang, Xiubing
Copyright Year	2015
Abstract	SYF2, also known as p29/NTC31/CBPIN, encodes a nuclear protein that interacts with Cyclin D-type binding-protein 1. SYF2 has been reported to be involved in pre-mRNA splicing and cell cycle regulation. In the present study, we observed that SYF2 was obviously upregulated in HCC tumor tissues and cell lines, and its level was positively correlated with the tumor grade and Ki-67 expression, as well as poor prognosis of HCC. In vitro, using serum starvation–refeeding experiment, our results suggested that SYF2 was upregulated in proliferating HCC cells, and was positive correlated with the expression of PCNA and Cyclin D1. In addition, depletion of SYF2 decreased PCNA and Cyclin D1 levels. Accordingly, interference of SYF2 resulted in cells cycle arrest at G1/S phase in Huh7 HCC cells. Furthermore, we found that SYF2 might interact with Cyclin D1 and could confer doxorubicin resistance in HCC cells. These findings revealed that SYF2 might play a regulatory role in the proliferation of HCC cells. In summary, SYF2 may be a novel prognostic marker and serve as a potential therapeutic target in HCC.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	410
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Springer US
Publisher Date	2015-08-11
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	SYF2 Hepatocellular carcinoma Cyclin D1 Prognosis Cell proliferation Biochemistry Medical Biochemistry Oncology Cardiology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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