NDLI: Differential expression of caveolin-1 and caveolin-3: potential marker for cardiac toxicity subsequent to chronic ozone inhalation

Content Provider	Springer Nature Link
Author	Sethi, Rajat Manchanda, Shubham Perepu, Rama Surya Prakash Kumar, Ajay Garcia, Carlos Kennedy, Richard H. Palakurthi, Srinath Dostal, David
Copyright Year	2012
Abstract	Earlier studies from our laboratory have shown myocardial dysfunction subsequent to chronic O$_{3}$ exposure in rats may be associated with a decrease in antioxidant reserve and increased activity of inflammatory mediators. The present study tested the hypothesis that O$_{3}$-induced cardiac dysfunction in healthy adult rats may be due to changes in caveolin-1 and caveolin-3 levels. Sprague–Dawley rats were exposed 8 h/day for 28 and 56 days to filtered air or 0.8 ppm O$_{3}$. In order to assess the chronic effects to O$_{3}$, in vivo cardiac function was assessed by measuring LVDP, 24 h after termination of O$_{3}$ exposure. Compared to rats exposed to filtered air, LVDP values significantly decreased in all O$_{3}$-exposed animals. This attenuation of cardiac function was associated with increased myocardial TNF-α levels and decreased myocardial activities of superoxidase dismutase. Progressive increases in the expression of myocardial TNF-α in 28 days and 56 days O$_{3}$-exposed animals were followed by decreases in cardiac caveolin-1 levels. On the other hand, differential changes in the expression of caveolin-3 in hearts from 28 and 56 days O$_{3}$-exposed animals were independent of intra-cardiac TNF-α levels. These novel findings suggest the interesting possibility that a balance between caveolin-1 and caveolin-3 may be involved in O$_{3}$-mediated cardiac toxicity.
Starting Page	9
Ending Page	15
Page Count	7
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	369
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Springer US
Publisher Date	2012-07-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Environmental pollutants Ozone Cardiovascular disease Cardiac toxicity Myocardial dysfunction Oxidative stress Caveolin Inflammation Superoxide dismutase Cardiology Oncology Medical Biochemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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