NDLI: Association of L55M and Q192R polymorphisms in paraoxonase 1 (PON1) gene with breast cancer risk and their clinical significance

Content Provider	Springer Nature Link
Author	Hussein, Yousri M. Gharib, Amal F. Etewa, Rasha L. ElSawy, Wael H.
Copyright Year	2011
Abstract	The HDL-associated paraoxonase (PON) activities play a role in decreasing oxidative stress, which is known to contribute to cancer development. The aim of this study was to examine the relation between the PON1 L55M and Q192R polymorphisms and breast cancer (BC) risk in Egyptian females and to analyze their relation to clinicopathological parameters of BC. Both polymorphisms were characterized in 100 BC Egyptian females and 100 healthy women who had no history of any malignancy by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) method, using DNA from peripheral blood in a case control study. With respect to PON1 L55M, the mutated allele (M) frequency was found in 70.5% in BC patients and in 53.5% in controls; the M allele was significantly associated with an increased risk of BC (adjusted odds ratio (OR$_{adj}$) 2.07, 95% confidence interval (95% CI) 1.37–3.13; P = 0.011). The homozygous mutant genotype (MM) significantly increased the risk of BC (OR$_{adj}$ 2.07, 95% CI 1.17–3.64, P = 0.011). However, as regard PON1 Q192R, the R mutated allele frequency was found in 28.5% in BC patients and in 33% in controls, the women who were QR heterozygotes (OR$_{adj}$ 0.96, 95% CI 0.55–1.68) or RR homozygotes (OR$_{adj}$ 0.64, 95% CI 0.25–1.63), and R allele (OR$_{adj}$ 0.81, 95% CI 0.53–1.42) did not show any risk for BC. Both PON1 L55M and Q192R polymorphisms genotype frequencies were not related to patient’s age (P = 0.94 and 0.72, respectively). M allele genotypes (LM/MM) carriers showed significant association only with nodal metastases (P = 0.02) but not with other clinicopathologic parameters. However, R allele genotype (QR/RR) carriers showed insignificant correlation with clinicopathological parameters. In conclusion, our results suggest that the M allele of L55M polymorphism could be a suitable marker for BC susceptibility and tumor prognosis in Egyptian women.
Starting Page	117
Ending Page	123
Page Count	7
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	351
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Springer US
Publisher Date	2011-01-13
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Breast cancer Paraoxonase gene polymorphisms Cardiology Oncology Biochemistry Medical Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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