NDLI: Reactive oxygen species mediated tissue damage in high energy proton irradiated mouse brain

Content Provider	Springer Nature Link
Author	Baluchamy, Sudhakar Ravichandran, Prabakaran Ramesh, Vani He, Zhenhua Zhang, Ye Hall, Joseph C. Jejelowo, Olufisayo Gridley, Daila S. Wu, Honglu Ramesh, Govindarajan T.
Copyright Year	2011
Abstract	Although radiation related research has been conducted extensively, the molecular toxicology and cellular mechanisms affected by proton radiation remain poorly understood. We recently reported that the high energy protons induce cell death through activation of apoptotic signaling genes; caspase 3 and 8 (Baluchamy et al. J Biol Chem 285:24769–24774, 2010). In this study, we investigated the effect of different doses of protons in in vivo mouse system, particularly, brain tissues. A significant dose-dependent induction of reactive oxygen species and lipid peroxidation and reduction of antioxidants; glutathione and superoxide dismutase were observed in proton irradiated mouse brain as compared to control brain. Furthermore, histopathology studies on proton irradiated mouse brain showed significant tissue damage as compared to control brain. Together, our in vitro and in vivo results suggest that proton irradiation alters oxidant and antioxidant levels in the cells to cause proton mediated DNA/tissue damage followed by apoptotic cell death.
Starting Page	189
Ending Page	195
Page Count	7
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	360
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Springer US
Publisher Date	2011-09-25
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Proton Reactive oxygen species (ROS) Lipid peroxidation Antioxidants Tissue damage Medical Biochemistry Oncology Cardiology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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