NDLI: SERCA pump isoform expression in endothelium of veins and arteries: Every endothelium is not the same

Content Provider	Springer Nature Link
Author	Khan, Islam Sandhu, Vicky Misquitta, Christine Grover, Ashok
Copyright Year	2000
Abstract	Endothelium from rat aorta expresses sarco/endoplasmic reticulum Ca$_{2+}$(SERCA) pump gene SERCA3 where as the smooth muscle expresses SERCA2. This has led to the postulate that vascular endothelium expresses SERCA3. To test this postulate, we examined the SERCA2 and SERCA3 mRNA expression in endothelium and smooth muscle dissected from coronary artery, coronary vein, aorta and vena cava of pig. Smooth muscle from all arteries and veins expressed only the SERCA2 mRNA. Endothelium from coronary artery, coronary vein and aorta expressed both SERCA2 and SERCA3 mRNA but the endothelium from vena cava did not express SERCA3 mRNA although it expressed SERCA2. These observations support the postulate that vascular endothelium expresses SERCA3 but the affirmation is equivocal because vena cava endothelium does not express SERCA3. (Mol Cell Biochem 000: 000-000, 1999)
Starting Page	11
Ending Page	15
Page Count	5
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	203
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2000-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cardiology Medical Biochemistry Oncology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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SERCA pump isoform expression in endothelium of veins and arteries: Every endothelium is not the same