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| Content Provider | Springer Nature Link |
|---|---|
| Author | Li, Guang Yong Cui, Wan Shou Zhou, Feng Gao, Zhe Zhu Xin, Hua Liu, Tao Li, Wei Ren Gong, Yan Qing Bai, Guang Yi Guo, Ying Lu Xin, Zhong Cheng |
| Copyright Year | 2012 |
| Abstract | To study pathological changes of fibromuscular system and the role of TGF-β1/Smad pathway in the urethra of a parturition-induced stress urinary incontinence (SUI) rat model. Twenty-eight 8-week-old Sprague-Dawley female rats at gestational day 16 were used and randomized into two groups: sham group and SUI group. After delivery, rats in the SUI group underwent postpartum vaginal balloon dilation and bilateral ovariectomy. 1 month after ovariectomy, urodynamics was assessed. Histological examination (Masson’s trichrome stain, picrosirius red stain, Hart’s elastin stain, Gordon & Sweet’s stain, and immunohistochemical stain) and Western blot were performed on urethral tissues. Both leak point pressure and maximal bladder capacity were significantly decreased in the balloon-injured ovariectomized rats, compared with the sham rats. Muscle was significantly decreased in the urethra of SUI rats compare with sham rats. Collagen I/III and reticular fibers from SUI group were also significantly lower than sham group. Meanwhile, elastic fibers and reticular fibers showed fragmentation and disorganization indicating impairment in the fibromuscular system in SUI rats. TGF-β1, MMP-9, and phosphorylated Smad2 (p-Smad2) were expressed significantly higher in SUI than in sham rats. Simulated birth trauma and menopause induced an upregulation of the TGF-β1/Smad pathway and impairment of the fibromuscular system in the urethra. |
| Starting Page | 329 |
| Ending Page | 335 |
| Page Count | 7 |
| File Format | |
| ISSN | 03008177 |
| Journal | Molecular and Cellular Biochemistry |
| Volume Number | 364 |
| Issue Number | 1-2 |
| e-ISSN | 15734919 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2012-02-04 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Extracellular matrix MMP-9 Stress urinary incontinence Smad2 TGF-β1 Medical Biochemistry Oncology Biochemistry Cardiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Clinical Biochemistry Molecular Biology |
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