NDLI: Salubrious effect of low molecular weight heparin on atherogenic diet-induced cardiac, hepatic and renal lipid peroxidation and collapse of antioxidant defences

Content Provider	Springer Nature Link
Author	Deepa, P.R. Varalakshmi, P.
Copyright Year	2003
Abstract	The present work showcases the distressing picture of oxidative stress in the cardiac, hepatic and renal tissues, in an experimental model based on early phase atherogenesis. The protection rendered by LMWH intervention forms part of the same study. Male Wistar rats of 140 ± 10 g were categorized as four groups. One group served as untreated control and another as LMWH drug control group. Two groups were fed a hypercholesterolemic atherogenic diet (rat chow supplemented with 4% cholesterol, 1% cholic acid and 0.5% thiouracil; CCT diet) for 2 weeks; one of these groups received LMWH treatment of 300 μg/day/rat for 7 days. The biochemical index of tissue lipid peroxidation (LPO) was assessed in terms of MDA formation. Heart, liver and kidney tissues of CCT-diet fed rats showed significantly elevated levels of LPO. In the early phase atherosclerotic group, we observed abnormal changes in the activities/levels of tissue enzymic (superoxide dismutase, catalase and glutathione peroxidase) and non-enzymic (reduced glutathione, ascorbate and α-tocopherol) antioxidants. We report normalized LPO levels and antioxidant defences in the atherogenic rats treated with LMWH. Thus the present study highlights the hepatic, cardiac and renal oxidative changes induced by experimental atherogenesis, and the protection rendered by LMWH treatment in atherosclerotic cardiovascular conditions.
Starting Page	111
Ending Page	116
Page Count	6
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	254
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2003-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cardiology Medical Biochemistry Oncology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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