NDLI: Gene expression profiling during thymus ontogeny and its association with TCRVβ8.1-Dβ2.1 rearrangements of inbred mouse strains

Content Provider	Springer Nature Link
Author	Espanhol, Aline R. Macedo, Cláudia Junta, Cristina M. Cardoso, Renato Sousa Victorero, Geneviève Loriod, Beatrice Nguyen, Catherine Jordan, Bertrand Passos, Geraldo A.S.
Copyright Year	2003
Abstract	The V(D)J recombination of TCRα and β in early developing T-cells is a highly modulated phenomenon initiated and completed by recombinase complex (RAG-1 and RAG-2), and regulated by other gene products such as interleukins. To further evaluate the association of several other gene products with the evolution of TCRVβ8.1 V(D)J rearrangements in vivo, the mRNA expression levels of seven interleukins, three cytokines, receptors TCRVβ8.1 and IL-2Rβ, MHC-I/MHC-II, RAG-1/RAG-2 and retroviral superantigen MMTV(SW) were measured by RT-PCR during the fetal development of the thymus of three inbred mouse strains (Balb-c, C57Bl/6 and CBA/J). Clustering using the Tree View software, was used to organize these genes based on similarity of expression patterns. Each strain displayed a different expression profile during thymus ontogeny.During the late developmental stage the most evident association was the kinetics of MMTV(SW) retrovirus, IL-2Rβ and IL-7 overexpression with reduction of TCRVβ8.1-Dβ2.1 rearrangement in the thymus of CBA/J mice. These data suggest a susceptibility of this strain to expression of MMTV(SW) upon reduction of the rearranged TCRVβ8.1-Dβ2.1 segment in developing thymocytes, with parallel IL-7 overexpression.
Starting Page	223
Ending Page	228
Page Count	6
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	252
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2003-01-01
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cardiology Medical Biochemistry Oncology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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