NDLI: The proteoglycan osteoglycin/mimecan is correlated with arteriogenesis

Content Provider	Springer Nature Link
Author	Kampmann, Andreas Fernández, Borja Deindl, Elisabeth Kubin, Thomas Pipp, Frederic Eitenmüller, Inka Hoefer, Imo E. Schaper, Wolfgang Zimmermann, René
Copyright Year	2008
Abstract	Arteriogenesis or collateral growth is able to compensate for the stenosis of major arteries. Using differential display RT-PCR on growing and quiescent collateral arteries in a rabbit femoral artery ligation model, we cloned the rabbit full-length cDNA of osteoglycin/mimecan. Osteoglycin was present in the adventitia of collateral arteries as a glycosylated protein without keratan sulfate side chains, mainly produced by smooth muscle cells (SMCs) and perivascular fibroblasts. Northern blot, Western blot, and immunohistochemistry confirmed a collateral artery-specific downregulation of osteoglycin from 6 h to 3 weeks after the onset of arteriogenesis. Treatment of primary SMCs with the arteriogenic protein fibroblast growth factor-2 (FGF-2) resulted in a similar reduction of osteoglycin expression as observed in vivo. Application of the FGF-2 inhibitor polyanethole sulfonic acid (PAS) blocked the downregulation of osteoglycin and interfered with arteriogenesis. From our study we conclude that downregulation of osteoglycin is a fundamental requirement for proper arteriogenesis.
Starting Page	15
Ending Page	23
Page Count	9
File Format	PDF
ISSN	03008177
Journal	Molecular and Cellular Biochemistry
Volume Number	322
Issue Number	1-2
e-ISSN	15734919
Language	English
Publisher	Springer US
Publisher Date	2008-11-04
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Gene expression Smooth muscle cells Collateral arteries Fibroblast growth factor-2 Proteoglycans Differential display Cardiology Oncology Medical Biochemistry Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Clinical Biochemistry Molecular Biology

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The proteoglycan osteoglycin/mimecan is correlated with arteriogenesis

The proteoglycan osteoglycin/mimecan is correlated with arteriogenesis

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