NDLI: Polymorphism of the Genome Region Coding for Protease and Reverse Transcriptase in HIV Type 1 Subtype A Variants Prevailing in CIS Countries

Please wait, while we are loading the content...

Dynamic Binding of the Human Telomeric Protein TRF1 to Intrachromosomal Blocks (TTAGGG)$_{n}$ in Live Chinese Hamster Cells Found to Depend on Transcription

Physicochemical Basis of RecA Filamentation on Single-Stranded DNA

Arrangement of the Template 3′ of the A-Site Codon on the Human 80S Ribosome

Folding/Unfolding Kinetics of Apomyoglobin

The Key Role of Large Clusters of Polar Residues of RNA-Binding Proteins in the Formation of Complexes with RNA

On the Prediction of Folding Nuclei in Globular Proteins

Development of a Synthetic Positive Control Which Also Detects Plasmid Contamination in Diagnostic Polymerase Chain Reaction

Neutralizing Monoclonal Antibodies Cross-React with Fusion Proteins Encoded by 129L of the Ectromelia Virus and A30L of the Variola Virus

Comparison of the Interferon γ-Binding Proteins of the Variola and Monkeypox Viruses

Polymorphism of the Genome Region Coding for Protease and Reverse Transcriptase in HIV Type 1 Subtype A Variants Prevailing in CIS Countries

Expression Regulation of the Amino Acid Biosynthesis and Aminoacyl-tRNA Synthase Genes in Actinobacteria

Algorithm for a Large-Scale Search for T-Box Transcription Regulation in Bacteria

Errata ( Molecular Biology , Volume 39 , Issue 6 )

Molecular Biology : Volume 39, Issue 5, September 2005

Molecular Biology : Volume 39, Issue 4, July 2005

Molecular Biology : Volume 39, Issue 3, May 2005

Molecular Biology : Volume 39, Issue 2, March 2005

Molecular Biology : Volume 39, Issue 1, January 2005

Molecular Biology : Volume 38

Molecular Biology : Volume 37

Molecular Biology : Volume 36

Molecular Biology : Volume 35

Molecular Biology : Volume 34

Polymorphism of the Genome Region Coding for Protease and Reverse Transcriptase in HIV Type 1 Subtype A Variants Prevailing in CIS Countries

Content Provider	Springer Nature Link
Author	Sukhava, A. L. Roudinskii, N. I. Bogoslovskaya, E. V. Kruglova, A. I. Bashkirova, L. Yu. Tsygava, G. M. Shipulin, G. A. Kazenva, E. V. Alikina, Yu. I. Zverev, S. Ya. Grishechkin, A. E. Pokrovsky, V. V. Bobkova, M. R. Bobkov, A. F.
Copyright Year	2005
Abstract	The pol nucleotide sequences coding for protease and reverse transcriptase were examined to study the frequency of drug resistance mutations in HIV-1 subtype A in Russia. The sample included 141 HIV-infected subjects who had never received antiretroviral drugs before. Primary resistance mutations occurred at a low (less than 1%) frequency, while unusually high frequencies were observed for the secondary mutations causing substitutions V77I in protease (67%) and A62V in reverse transcriptase (63%). The V77I and A62V mutations were associated in most cases. HIV-1 isolates carrying both mutations (Mut$_{V77I/A62V}$) had several synonymous substitutions in pol, which was indicative of their common origin. Examination of a larger sample of HIV-1 isolates (N = 319) by hybridization with biological microchips and by restriction enzyme analysis showed that the Mut$_{V77I/A62V}$ variant dominated in Russia in terms of both frequency (56%) and geographic distribution, prevailing in regions with the highest incidence of HIV-1 infection (e.g., Irkutsk, Samara, and Moscow regions). In addition, analysis revealed the genotypes that contained none of the V77I and A62V mutations or only one of them. The evolutionary relationships of the four HIV-1 variants and the role of pol gene polymorphism in replicative activity and drug resistance of HIV-1 are discussed.
Starting Page	934
Ending Page	941
Page Count	8
File Format	PDF
ISSN	00268933
Journal	Molecular Biology
Volume Number	39
Issue Number	6
e-ISSN	16083245
Language	English
Publisher	Nauka/Interperiodica
Publisher Date	2005-01-01
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	HIV-1 subtype A protease reverse transcriptase polymorphism antiretroviral therapy drug resistance mutations Human Genetics Life Sciences Biochemistry
Content Type	Text
Resource Type	Article
Subject	Structural Biology Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance.

HIV-1 Protease and Reverse-Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance

Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase.

Improving fold resistance prediction of HIV-1 against protease and reverse transcriptase inhibitors using artificial neural networks

HIV-1 Pol Gene Polymorphism and Antiretroviral Resistance Mutations in Treatment-Naive Adult Patients in French Guiana Between 2006 and 2012

Analysis of HIV- type 1 protease and reverse transcriptase in Brazilian children failing highly active antiretroviral therapy (HAART)

Reverse transcriptase drug resistance mutations in HIV-1 subtype C infected patients on ART in Karonga District, Malawi

Human Immunodeficiency Virus type 1 reverse transcriptase and protease gene mutations

Characterization of Genotypic Mutations and Antiretroviral Resistance among Viremic HIV-Infected Patients in a High HIV Prevalence Area: Treatment Challenge and Transmission Risk

Polymorphism of the Genome Region Coding for Protease and Reverse Transcriptase in HIV Type 1 Subtype A Variants Prevailing in CIS Countries

Similar Documents

HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance.

HIV-1 Protease and Reverse-Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance

Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase.

Improving fold resistance prediction of HIV-1 against protease and reverse transcriptase inhibitors using artificial neural networks

HIV-1 Pol Gene Polymorphism and Antiretroviral Resistance Mutations in Treatment-Naive Adult Patients in French Guiana Between 2006 and 2012

Analysis of HIV- type 1 protease and reverse transcriptase in Brazilian children failing highly active antiretroviral therapy (HAART)

Reverse transcriptase drug resistance mutations in HIV-1 subtype C infected patients on ART in Karonga District, Malawi

Human Immunodeficiency Virus type 1 reverse transcriptase and protease gene mutations

Characterization of Genotypic Mutations and Antiretroviral Resistance among Viremic HIV-Infected Patients in a High HIV Prevalence Area: Treatment Challenge and Transmission Risk

Polymorphism of the Genome Region Coding for Protease and Reverse Transcriptase in HIV Type 1 Subtype A Variants Prevailing in CIS Countries