NDLI: Structural and Functional Topography of Human Ribosomes Deduced from Crosslinking with mRNA Analogs, Oligoribonucleotide Derivatives

Content Provider	Springer Nature Link
Author	Graifer, D. M. Karpova, G. G.
Copyright Year	2001
Abstract	Reviewed are data on the position of template codons with respect to 18S rRNA and certain proteins on human ribosome obtained using a set of mRNA analogs, oligoribonucleotide derivatives carrying alkylating or photoactivatable groups at different positions. A comparison of data on the template position on the human and Escherichia coliribosomes has revealed both the similarity in the structure of the mRNA-binding site of bacterial and mammalian ribosomes and the peculiarities of the functioning of mammalian (in particular, human) ribosomes. The similarity manifests itself in that the template codons at the A-, P-, and E-sites of bacterial and human ribosomes are surrounded by similar nucleotides (occupying similar positions in the conserved regions of secondary structure) of small subunit rRNA. The template forms a loop whose foot is in proximity to the 530 stem–loop conserved region of rRNA. The specific features of mammalian ribosomes appear to be associated with their lower conformational mobility as compared with bacterial ribosomes, owing to which their interaction with the template involves a lesser number of molecular contacts.
Starting Page	496
Ending Page	508
Page Count	13
File Format	PDF
ISSN	00268933
Journal	Molecular Biology
Volume Number	35
Issue Number	4
e-ISSN	16083245
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2001-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Life Sciences Biochemistry
Content Type	Text
Resource Type	Article
Subject	Structural Biology Biophysics

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The mRNA Codon Environment at the P and E Sites of Human Ribosomes Deduced from Photocrosslinking with pUUUGUU Derivatives

Crosslinking of mRNA Analog, pUUAGUAUUUAUU Derivative with Photoactivatable Group at the Guanosine Residue, with Human 80S Ribosomes

Protein Environment of the Sense Codon of the Template in the A Site of the Human Ribosome as Inferred from Crosslinking to Oligoribonucleotide Derivatives

Arrangement of the Sense and Stop Codons of the Template in the A Site of the Human Ribosome as Inferred from Crosslinking with Oligonucleotide Derivatives

Class-1 Translation Termination Factors Are Functional Analogs of Aminoacyl-tRNAs

Escherichia coli Ribosomes as a Model for Testing New Photoactivated tRNA Analogs Containing 6-Thioguanosine Residues

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Structural and Functional Topography of Human Ribosomes Deduced from Crosslinking with mRNA Analogs, Oligoribonucleotide Derivatives

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