NDLI: Coordinated interaction of multifunctional members of the p53 family determines many key processes in multicellular organisms

Please wait, while we are loading the content...

Combinatorial libraries of phage antibodies: Application for analysis of gene segments encoding variable domains of autoantibodies to tumor necrosis factor

Mechanisms of HIV-1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors

Cell defense systems against oxidative stress and endoplasmic reticulum stress: Mechanisms of regulation and the effect of hepatitis C virus

Baculovirus expression systems for production of recombinant proteins in insect and mammalian cells

Paradoxes of replication of RNA of a bacterial virus

Regulation of death receptor-induced apoptosis induced via CD95/Fas and other death receptors

Coordinated interaction of multifunctional members of the p53 family determines many key processes in multicellular organisms

Erratum to: “On the role of the selective silencer freud-1 in the regulation of the brain 5-HT$_{1A}$ receptor gene expression” [Molecular Biology 44, 795 (2010)]

Molecular Biology : Volume 44

Molecular Biology : Volume 43

Molecular Biology : Volume 42

Molecular Biology : Volume 41

Molecular Biology : Volume 40

Molecular Biology : Volume 39

Molecular Biology : Volume 38

Molecular Biology : Volume 37

Molecular Biology : Volume 36

Molecular Biology : Volume 35

Molecular Biology : Volume 34

Coordinated interaction of multifunctional members of the p53 family determines many key processes in multicellular organisms

Content Provider	Springer Nature Link
Author	Vilgelm, A. E. Zaika, A. I. Prassolov, V. S.
Copyright Year	2011
Abstract	For the first time, p53 was found in complex with the viral large T-antigen in cells transformed with the small DNA virus SV40. p53 cDNA was cloned in the early 1980s, and the full-length p53 gene was cloned soon afterwards. The p53 family is comprised of three genes—TP53, TP63, and TP73—each of which is expressed as a set of structurally and functionally different isoforms. All of them intensely interact with each other, forming a united functional network of proteins. The review discusses the evolution of the p53 family and the significance of all its members in embryo development, reproduction, regeneration, regulation of aging and lifespan, and defense against cancer. Special attention is paid to the role of poorly studied members of the p53 family, p63 and p73, in carcinogenesis and tumor progression. Different isoforms of these proteins might exert opposite effects on these processes.
Starting Page	156
Ending Page	171
Page Count	16
File Format	PDF
ISSN	00268933
Journal	Molecular Biology
Volume Number	45
Issue Number	1
e-ISSN	16083245
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2011-02-22
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	tumor suppressors p53 p63 p73 genetic stability apoptosis carcinogenesis aging cell growth regulation Human Genetics Biochemistry Life Sciences
Content Type	Text
Resource Type	Article
Subject	Structural Biology Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Versatile functions of p53 protein in multicellular organisms

The p53 Gene Family: Control of Cell Proliferation and Developmental Programs

The Tumor Suppressors p53, p63, and p73 Are Regulators of MicroRNA Processing Complex

Tumor Suppressors p53, p63TAα, p63TAy, p73α, and p73β Use Distinct Pathways to Repress Telomerase Expression

Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1

Expression and clinical implications of P53, P63, and P73 protein in malignant tumor of the parotid gland

New Insights in Thyroid Cancer and p53 Family Proteins

p73 expression modulates p63 and Mdm2 protein presence in complex with p53 family-specific DNA target sequence in squamous cell carcinogenesis

Crystal Structures of the DNA-binding Domain Tetramer of the p53 Tumor Suppressor Family Member p73 Bound to Different Full-site Response Elements

Coordinated interaction of multifunctional members of the p53 family determines many key processes in multicellular organisms

Similar Documents

Versatile functions of p53 protein in multicellular organisms

The p53 Gene Family: Control of Cell Proliferation and Developmental Programs

The Tumor Suppressors p53, p63, and p73 Are Regulators of MicroRNA Processing Complex

Tumor Suppressors p53, p63TAα, p63TAy, p73α, and p73β Use Distinct Pathways to Repress Telomerase Expression

Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1

Expression and clinical implications of P53, P63, and P73 protein in malignant tumor of the parotid gland

New Insights in Thyroid Cancer and p53 Family Proteins

p73 expression modulates p63 and Mdm2 protein presence in complex with p53 family-specific DNA target sequence in squamous cell carcinogenesis

Crystal Structures of the DNA-binding Domain Tetramer of the p53 Tumor Suppressor Family Member p73 Bound to Different Full-site Response Elements

Coordinated interaction of multifunctional members of the p53 family determines many key processes in multicellular organisms