NDLI: Possible role of autophagy activation in stimulation of regeneration

Content Provider	Springer Nature Link
Author	Vishnyakova, Kh. S. Popov, K. V. Vorotelyak, E. A. Faizullin, R. R. Artyukhov, A. S. Yegorov, Y. E.
Copyright Year	2013
Abstract	Human cell aging is irregular. Senescent cells often impair the function of their neighbour nonsenescent cells. Stimulation of tissue regeneration is of potential applied significance for medicine, in particular, for geriatrics. One of the possible ways to induce regeneration consists of a selective removal of senescent and damaged cells from the tissue. Studies of the mechanism of action for Satura Rosta Balm, which stimulates the hair growth, showed that the balm does not stimulate proliferation of various human cells, nor does it improve the cell resistance to stress. Oppositely, the balm exerted a cytotoxic effect in oxidative stress with-out increasing the production of reactive oxygen species. Further investigations show that the balm increases the transcriptional activity of the p53 gene, activates autophagy, and induces weak adipogenic differentiation. A hypothesis of autophagic regeneration is discussed, suggesting that selective autophagic death of senescent and damaged cells, which experience oxidative stress, triggers regeneration, which may be stimulated by both a rejuvenating effect of an increase in autophagy and a release of additional metabolites.
Starting Page	692
Ending Page	700
Page Count	9
File Format	PDF
ISSN	00268933
Journal	Molecular Biology
Volume Number	47
Issue Number	5
e-ISSN	16083245
Language	English
Publisher	Springer US
Publisher Date	2013-10-11
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	autophagy proliferation hair hair loss human cells Satura® Rosta regeneration Life Sciences Biochemistry Human Genetics
Content Type	Text
Resource Type	Article
Subject	Structural Biology Biophysics

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