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  1. International Journal of Peptide Research and Therapeutics
  2. International Journal of Peptide Research and Therapeutics : Volume 20
  3. International Journal of Peptide Research and Therapeutics : Volume 20, Issue 4, December 2014
  4. The Emergence of Cyclic Peptides: The Potential of Bioengineered Peptide Drugs
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International Journal of Peptide Research and Therapeutics : Volume 23
International Journal of Peptide Research and Therapeutics : Volume 22
International Journal of Peptide Research and Therapeutics : Volume 21
International Journal of Peptide Research and Therapeutics : Volume 20
International Journal of Peptide Research and Therapeutics : Volume 20, Issue 4, December 2014
Antimicrobial and Antibiofilm Activity of Mauriporin, a Multifunctional Scorpion Venom Peptide
Simulated Interactions between Endothelin Converting Enzyme and Aβ Peptide: Insights into Subsite Recognition and Cleavage Mechanism
Effects of Apelin-13 on Rat Bone Marrow-Derived Mesenchymal Stem Cell Proliferation Through the AKT/GSK3β/Cyclin D1 Pathway
Mechanism of bFGF-binding Peptide Reversing Adriamycin Resistance in Human Gastric Cancer Cells
Roles of Hyp Residues in the Folding and Activity of μ-Conotoxin GIIIA, a Peptide Blocker of Muscle Sodium Channels
A Novel Fluorometric Method for the Selective Determination of Pro-Gly and Pro-Gly-Pro
Expression and Selection of Human Foxm1c Binding Peptides and Their Inhibitions on MCF7 Cancer Cells
The Host Defence Peptide LL-37 is Susceptible to Proteolytic Degradation by Wound Fluid Isolated from Foot Ulcers of Diabetic Patients
Synthesis and Characterization of Polysialic Acid–Uricase Conjugates for the Treatment of Hyperuricemia
To Determine Biologically Important Mutations in Oxytocin
The Evaluation of Dipeptidyl Peptidase (DPP)-IV, α-Glucosidase and Angiotensin Converting Enzyme (ACE) Inhibitory Activities of Whey Proteins Hydrolyzed with Serine Protease Isolated from Asian Pumpkin (Cucurbita ficifolia)
ACE-Inhibitory and Antioxidant Activity of Temporin-Ra Peptide: Biochemical Characterization and Molecular Modeling Study
Anticancer Activities of Antimicrobial BmKn2 Peptides Against Oral and Colon Cancer Cells
The Antiepileptic Effect of Ghrelin During Different Phases of the Estrous Cycle in PTZ-Induced Seizures in Rat
Modified Cysteine-Deleted Tachyplesin (CDT) Analogs as Linear Antimicrobial Peptides: Influence of Chain Length, Positive Charge, and Hydrophobicity on Antimicrobial and Hemolytic Activity
Purification and Characterization of Cold Adapted Trypsins from Antarctic krill (Euphausia superba)
The Emergence of Cyclic Peptides: The Potential of Bioengineered Peptide Drugs
Effects of Amino Acid Deletion on the Antiplasmodial Activity of Angiotensin II
Immune Response of the VEGF/bFGF Complex Peptide Vaccine and Function of Immune Antibodies in Inhibiting Migration of HUVEC Cells and Proliferation of Cancer Cells
Inhibition of Pore Formation by Blocking the Assembly of Staphylococcus aureus α-Hemolysin Through a Novel Peptide Inhibitor: an In Silco Approach
International Journal of Peptide Research and Therapeutics : Volume 20, Issue 3, September 2014
International Journal of Peptide Research and Therapeutics : Volume 20, Issue 2, June 2014
International Journal of Peptide Research and Therapeutics : Volume 20, Issue 1, March 2014
International Journal of Peptide Research and Therapeutics : Volume 19
International Journal of Peptide Research and Therapeutics : Volume 18
International Journal of Peptide Research and Therapeutics : Volume 17
International Journal of Peptide Research and Therapeutics : Volume 16
International Journal of Peptide Research and Therapeutics : Volume 15
International Journal of Peptide Research and Therapeutics : Volume 14
International Journal of Peptide Research and Therapeutics : Volume 13
International Journal of Peptide Research and Therapeutics : Volume 12
International Journal of Peptide Research and Therapeutics : Volume 11
International Journal of Peptide Research and Therapeutics : Volume 10
International Journal of Peptide Research and Therapeutics : Volume 9
International Journal of Peptide Research and Therapeutics : Volume 8
International Journal of Peptide Research and Therapeutics : Volume 7
International Journal of Peptide Research and Therapeutics : Volume 6
International Journal of Peptide Research and Therapeutics : Volume 5
International Journal of Peptide Research and Therapeutics : Volume 4
International Journal of Peptide Research and Therapeutics : Volume 3

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The Emergence of Cyclic Peptides: The Potential of Bioengineered Peptide Drugs

Content Provider Springer Nature Link
Author Thapa, Parashar Espiritu, Michael J. Cabalteja, Chi Bingham, Jon Paul
Copyright Year 2014
Abstract Studies into N- to C-terminal cyclic peptide backbone structures have provided for the lateral transition of important principles and strategies that clearly resonate within the world of bioactive peptides and peptide toxins. The ability to transform peptide biologics into stable and orally active constituents represents a major pharmacological achievement. This progression has been forthcoming and is potentially intensified by the diminishing expectations of current small organic molecule pipelines. While still in the early stages of development, cyclic peptide drug leads have gained the attention of the pharmaceutical industry, however their true potential is still very much unknown.
Starting Page 545
Ending Page 551
Page Count 7
File Format PDF
ISSN 15733149
Journal International Journal of Peptide Research and Therapeutics
Volume Number 20
Issue Number 4
e-ISSN 15733904
Language English
Publisher Springer Netherlands
Publisher Date 2014-08-10
Publisher Place Dordrecht
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Cyclic peptides Small organic molecules New chemical entities Peptide therapeutics Pharmaceutical industry Biochemistry Animal Anatomy / Morphology / Histology Polymer Sciences Pharmaceutical Sciences/Technology Pharmacology/Toxicology Molecular Medicine
Content Type Text
Resource Type Article
Subject Analytical Chemistry Drug Discovery Biochemistry Molecular Medicine Bioengineering
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