NDLI: Chemical Synthesis of a Fluorescent IGF-II Analogue

Content Provider	Springer Nature Link
Author	Cottam, Jade M. Scanlon, Denis B. Karas, John A. Calabrese, Antonio N. Pukala, Tara L. Forbes, Briony E. Wallace, John C. Abell, Andrew D.
Copyright Year	2012
Abstract	Insulin-like growth factor II (IGF-II) is a protein with high structural and sequence similarity to insulin. Unlike insulin, it binds both the type 1 IGF receptor and the exon 11- isoform of the insulin receptor with high affinity. The overexpression and up regulation of IGF-II has been associated with the progression of various forms of cancer. The exact binding mechanism of IGF-II to its high affinity receptors is still not completely understood. Herein we describe the successful synthesis of a novel fluorescent IGF-II protein (F19Cou IGF-II), where residue 19 (phenylalanine) has been replaced by a fluorescent chromophore (coumaryl glycine). This novel coumaryl IGF-II analogue will be a useful tool for analysing the receptor interaction mechanisms in future studies.
Starting Page	61
Ending Page	69
Page Count	9
File Format	PDF
ISSN	15733149
Journal	International Journal of Peptide Research and Therapeutics
Volume Number	19
Issue Number	1
e-ISSN	15733904
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-12-07
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Insulin-like growth factor II Coumarin Solid phase peptide synthesis Pseudoproline Aggregation Biochemistry Animal Anatomy / Morphology / Histology Polymer Sciences Pharmaceutical Sciences/Technology Pharmacology/Toxicology Molecular Medicine
Content Type	Text
Resource Type	Article
Subject	Analytical Chemistry Drug Discovery Biochemistry Molecular Medicine Bioengineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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