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| Content Provider | Springer Nature Link |
|---|---|
| Author | Abd Elfattah, Ehab F. |
| Copyright Year | 2010 |
| Abstract | The current status and panel count data frequently arise from cancer and tumorigenicity studies when events currently occur. A common and widely used class of two sample tests, for current status and panel count data, is the permutation class. We manipulate the double saddlepoint method to calculate the exact mid-p-values of the underlying permutation distributions of this class of tests. Permutation simulations are replaced by analytical saddlepoint computations which provide extremely accurate mid-p-values that are exact for most practical purposes and almost always more accurate than normal approximations. The method is illustrated using two real tumorigenicity panel count data. To compare the saddlepoint approximation with the normal asymptotic approximation, a simulation study is conducted. The speed and accuracy of the saddlepoint method facilitate the calculation of the confidence interval for the treatment effect. The inversion of the mid-p-values to calculate the confidence interval for the mean rate of development of the recurrent event is discussed. |
| Ending Page | 472 |
| Page Count | 12 |
| Starting Page | 461 |
| File Format | |
| ISSN | 13807870 |
| e-ISSN | 15729249 |
| Journal | Lifetime Data Analysis |
| Issue Number | 3 |
| Volume Number | 17 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2010-12-08 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Hypothesis testing Current status data Permutation tests Statistics for Life Sciences, Medicine, Health Sciences Mid-p-value Applications to biology and medical sciences Statistics Panel data Statistics for Business/Economics/Mathematical Finance/Insurance Two-sample tests Operations Research/Decision Theory Quality Control, Reliability, Safety and Risk General biostatistics Approximations to distributions (nonasymptotic) Saddlepoint approximation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Applied Mathematics Medicine |
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