NDLI: Effects of 2,3-butanedione monoxime on excitation–contraction coupling in frog twitch fibres

Content Provider	Springer Nature Link
Author	Armas, Rafael De González, Silvia Brum, Gustavo Pizarro, Gonzalo
Copyright Year	1998
Abstract	10 and 30mm 2,3-butanedione monoxime (BDM) applied extracellularly to voltage-clamped frog skeletal muscle twitch fibres suppressed both Ca2+ release flux and intramembranous charge movement. Both effects could be clearly separated. The early peak of the Ca2+ release flux was suppressed at every test voltage. The steady level attained at the end of a 100ms clamp depolarization was relatively spared for lower depolarizing pulses, but was as suppressed as the peak at voltages above −20mV. The intramembranous charge movement was affected mainly in the Iγ component. The drug had a distinct effect on the kinetics of the intramembranous charge movement current around the threshold for Ca2+ release. The three kinetic components of Iγ were simultaneously affected. For more positive depolarizations where the kinetic effect was not evident, the oxime had no significant effect on the charge moved. Under conditions in which Iγ was absent (i.e. stretched fibres, intracellular solutions containing 6 to 10mm BAPTA), treatment with 10mm BDM had a small, not significant suppressive effect on the maximum charge moved (Qmax), while it affected Ca2+ release significantly. When 10mm BDM was applied in the presence of 0.2mm tetracaine, the local anaesthetic-resistant Ca2+ release flux was not further suppressed by the oxime.
Starting Page	961
Ending Page	977
Page Count	17
File Format	PDF
ISSN	01424319
Journal	Journal of Muscle Research & Cell Motility
Volume Number	19
Issue Number	8
e-ISSN	15732657
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1998-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Molecular Medicine Proteomics Cell Biology Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

2,3-Butanedione monoxime (BDM) as a myosin inhibitor

Action of perchlorate on the voltage dependent inactivation of excitation–contraction coupling in frog skeletal muscle fibres

Effects of the PKA inhibitor H-89 on excitation–contraction coupling in skinned and intact skeletal muscle fibres

2,3-Butanedione monoxime (BDM), a potent inhibitor of actin–myosin interaction, induces ion and fluid transport in MDCK monolayers

Excitation–contraction coupling and fatigue mechanisms in skeletal muscle: studies with mechanically skinned fibres

Multiple actions of 2,3-butanedione monoxime on contractile activation in frog twitch fibres.

Two inhibitors of store operated Ca$^{2+}$ entry suppress excitation contraction coupling in frog skeletal muscle

Differential effects of contractile potentiators on action potential-induced Ca$^{2+}$ transients of frog and mouse skeletal muscle fibres

Caffeine and excitation–contraction coupling in skeletal muscle: a stimulating story

Effects of 2,3-butanedione monoxime on excitation–contraction coupling in frog twitch fibres

Similar Documents

2,3-Butanedione monoxime (BDM) as a myosin inhibitor

Action of perchlorate on the voltage dependent inactivation of excitation–contraction coupling in frog skeletal muscle fibres

Effects of the PKA inhibitor H-89 on excitation–contraction coupling in skinned and intact skeletal muscle fibres

2,3-Butanedione monoxime (BDM), a potent inhibitor of actin–myosin interaction, induces ion and fluid transport in MDCK monolayers

Excitation–contraction coupling and fatigue mechanisms in skeletal muscle: studies with mechanically skinned fibres

Multiple actions of 2,3-butanedione monoxime on contractile activation in frog twitch fibres.

Two inhibitors of store operated Ca$^{2+}$ entry suppress excitation contraction coupling in frog skeletal muscle

Differential effects of contractile potentiators on action potential-induced Ca$^{2+}$ transients of frog and mouse skeletal muscle fibres

Caffeine and excitation–contraction coupling in skeletal muscle: a stimulating story

Effects of 2,3-butanedione monoxime on excitation–contraction coupling in frog twitch fibres