NDLI: Magnesium aluminium silicate–gentamicin complex for drug delivery systems : Preparation, physicochemical characterisation and release profiles of the drug

Content Provider	Springer Nature Link
Author	Rapacz Kmita, A. Stodolak Zych, E. Dudek, M. Gajek, M. Ziąbka, M.
Copyright Year	2016
Abstract	This paper presents the characteristics of magnesium aluminium silicate–gentamicin complexes for drug delivery systems. The work describes the results of studies on the successful introduction of gentamicin (an aminoglycoside antibiotic) into the interlayers of smectite clay and examines the possible use of intercalated smectite as a carrier for sustained drug release. Characterisation of magnesium aluminium silicate–gentamicin complexes was carried out by means of X-ray diffraction, Fourier transform infrared spectroscopy, thermal analysis and scanning electron microscopy with EDX analysis. The possibility of using the gentamicin intercalated smectite as a carrier for sustained release of the drug was investigated during in vitro study, in which the release rate of gentamicin from the smectite clay matrix was monitored based on absorption at 330 nm using a UV–Vis spectrometer and the kinetic of drug release was evaluated based on the zero-order, first-order, Higuchi and Korsmeyer–Peppas models. The results confirmed the efficiency of intercalation and indicate the potential for introducing gentamicin into the interlayer space of montmorillonite. Accordingly, the obtained material may thus be used as a drug carrier in modulated drug delivery systems.
Starting Page	871
Ending Page	880
Page Count	10
File Format	PDF
ISSN	13886150
Journal	Journal of thermal analysis
Volume Number	127
Issue Number	1
e-ISSN	15882926
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-11-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Clays Gentamicin Drug release Intercalation Biomedical applications Physical Chemistry Analytical Chemistry Polymer Sciences Inorganic Chemistry Measurement Science and Instrumentation
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Preparation and physicochemical characterization of binary composites palygorskite–chitosan for drug delivery

Thermal behavior analysis of kaolinite–dimethylsulfoxide intercalation complex

The physicochemical/thermodynamic balance of advanced drug liposomal delivery systems

TG–MS–FTIR (evolved gas analysis) of kaolinite–urea intercalation complex

Isothermal crystallization of layered silicate/starch-polycaprolactone blend nanocomposites

Thermal behaviour of dickite-dimethylsulfoxide intercalation complex

Preparation and characterisation of ammonium polyphosphate intercalated layered double hydroxides composite by joint method with or without sonochemical technique

Modified organophilic montmorillonites/LDPE nanocomposites : Preparation and thermal characterization

The effects of magnesium and aluminium ions’ additions on the kinetics of titanium dioxide structural transformation

Magnesium aluminium silicate–gentamicin complex for drug delivery systems : Preparation, physicochemical characterisation and release profiles of the drug

Similar Documents

Preparation and physicochemical characterization of binary composites palygorskite–chitosan for drug delivery

Thermal behavior analysis of kaolinite–dimethylsulfoxide intercalation complex

The physicochemical/thermodynamic balance of advanced drug liposomal delivery systems

TG–MS–FTIR (evolved gas analysis) of kaolinite–urea intercalation complex

Isothermal crystallization of layered silicate/starch-polycaprolactone blend nanocomposites

Thermal behaviour of dickite-dimethylsulfoxide intercalation complex

Preparation and characterisation of ammonium polyphosphate intercalated layered double hydroxides composite by joint method with or without sonochemical technique

Modified organophilic montmorillonites/LDPE nanocomposites : Preparation and thermal characterization

The effects of magnesium and aluminium ions’ additions on the kinetics of titanium dioxide structural transformation

Magnesium aluminium silicate–gentamicin complex for drug delivery systems : Preparation, physicochemical characterisation and release profiles of the drug