NDLI: Compatibility study between ibuprofen and excipients in their physical mixtures

Content Provider	Springer Nature Link
Author	Tiţa, Bogdan Fuliaş, Adriana Szabadai, Zoltan Rusu, Gerlinde Bandur, Geza Tiţa, Dumitru
Copyright Year	2010
Abstract	The thermal techniques of analysis were used to assess the compatibility between ibuprofen (IB) and some excipients used in the development of extended released formulations. This study is a part of a systematic study undertaken to find and optimizes a general method of detecting the drug–excipient interactions, with the aim of predicting rapidly and assuring the long-term stability of pharmaceutical product and speeding up its marketing. The thermal properties of IB and its physical association as binary mixtures with some common excipients were evaluated by thermogravimetry/derivative thermogravimetry (TG/DTG) and differential scanning calorimetry. FT-IR spectroscopy and X-ray powder diffraction (XRPD) were used as complementary techniques to adequately implement and assist in interpretation of the thermal results. Based on their frequent use in preformulations nine different excipients: starch; microcrystalline cellulose (PH 101 and PH 102); colloidal silicon dioxide; lactose (monohydrate and anhydre); polyvinylpyrrolidone; magnesium stearate and talc were blended with IB. The samples were prepared by mixing the analyte and excipients in a proportion of 1:1 (w:w). The TG/DSC curves of the IB have shown a single stage of mass loss between 175 and 290 °C, respectively, an endothermic peak at 78.5 °C, which corresponds to the melting (literature T $_{m}$ = 75–78 °C).
Starting Page	517
Ending Page	527
Page Count	11
File Format	PDF
ISSN	13886150
Journal	Journal of thermal analysis
Volume Number	105
Issue Number	2
e-ISSN	15728943
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-12-16
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ibuprofen Thermal behaviour TG/DSC Drug–excipient compatibility Analytical Chemistry Physical Chemistry Inorganic Chemistry Measurement Science and Instrumentation Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

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