NDLI: Synthesis, spectroscopic, thermal characterization, and antimicrobial activity of miconazole drug and its metal complexes

Content Provider	Springer Nature Link
Author	Abd El Halim, Hanan F. ur El Dien, F. A. Mohamed, Gehad G. Mohamed, Nehad A.
Copyright Year	2011
Abstract	Metal complexes having the general composition [MCl$_{2}$(H$_{2}$O)$_{2}$(L)$_{2}$]·yH$_{2}$O (where y = 1–3, M = Mn(II), Cu(II), Co(II), Ni(II), and Zn(II) and L = miconazole drug = MCNZ) and [MCl$_{2}$(H$_{2}$O)$_{2}$(L)$_{2}$]Cl·3H$_{2}$O (where M = Cr(III) and Fe(III)) have been synthesized. All the synthesized complexes were identified and confirmed by elemental analyses, IR, diffused reflectance, and thermal analyses (TG and DTA) techniques as well as molar conductivity and magnetic moment measurements. The molar conductance data reveals that bivalent metal complexes are non-electrolytes while Cr(III) and Fe(III) complexes are electrolytes and of 1:1 type. IR spectral studies reveal that MCNZ is coordinated to the metal ions in a neutral unidentate manner with N donor site of the imidazole-N. On the basis of magnetic and solid reflectance spectral studies, an octahedral geometry has been assigned for the complexes. Detailed studies of the thermal properties of the complexes were investigated by thermogravimetry (TG) and differential thermal analyses (DTA) techniques and the activation thermodynamic parameters are calculated using Coats–Redfern method. The free MCNZ drug and its complexes were also evaluated against bacterial species (P. aeruginosa, S. aureus, B. subtilis, E. Coli) and fungi (A. fumigatus, P. italicum, and C. albicans) in vitro. The activity data show that the metal complexes have higher biological activity than the parent MCNZ drug.
Starting Page	883
Ending Page	892
Page Count	10
File Format	PDF
ISSN	13886150
Journal	Journal of thermal analysis
Volume Number	109
Issue Number	2
e-ISSN	15728943
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-07-24
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Miconazole Metal complexes Spectroscopic studies Thermal analyses Biological activity Analytical Chemistry Inorganic Chemistry Physical Chemistry Measurement Science and Instrumentation Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

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