NDLI: Grinding effect on levofloxacin hemihydrate

Content Provider	Springer Nature Link
Author	Pereira, Rafael Nicolay Fandaruff, Cinira Riekes, Maela Klüppel Monti, Gustavo A. Campos, Carlos Eduardo Maduro Cuffini, Silvia Lucia Silva, Marcos Antonio Segatto
Copyright Year	2014
Abstract	The grinding techniques were used in different pharmacotechnical process. The control of the effect of grinding in solid state properties of drugs is very important, mainly in hydrated drugs. Levofloxacin hemihydrate (LVF) is a good example of this type of compounds and a broad spectrum antibiotic of the fluoroquinolone drug class. The samples of LVF with and without grinding were studied using different characterization techniques such as thermogravimetry, differential scanning calorimetry, fourier-transformed infrared, X-ray powder diffraction, and hot stage microscopy. The purpose of the present study was to evaluate the effects of grinding in the dehydration and rehydration processes in levofloxacin hemihydrate. After heating, the samples lost water molecules and the rehydration process was modified depending on defects due to the grinding. At room temperature, the complete transformation to the hemihydrate form was detected only for the sample without grinding. On the other hand, the milled sample showed two phases, hydrate and anhydrate forms. Therefore, the defects in the crystalline structure would cause the irreversible transformation.
Starting Page	989
Ending Page	994
Page Count	6
File Format	PDF
ISSN	13886150
Journal	Journal of thermal analysis
Volume Number	119
Issue Number	2
e-ISSN	15882926
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-10-19
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Levofloxacin Hemihydrate Grinding Rehydration Physical Chemistry Analytical Chemistry Polymer Sciences Inorganic Chemistry Measurement Science and Instrumentation
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry

Thermal Decomposition of Copper(I) Thiocarbamide Chloride Hemihydrate

Implications of Fine Grinding in Mineral Processing Mechanochemical approach

Effect of mechanical grinding on the reaction pathway and kinetics of the thermal decomposition of hydromagnesite

Effect of grinding on the dehydration behavior of nedocromil sodium hydrates

Thermal investigation of strontium acetate hemihydrate in nitrogen gas

Introduction—Polymer physics section

Study of dehydration and rehydration processes of portlandite in mature and young cement pastes

Improvement of surface cementitious properties of coarse fly ash by dehydration and rehydration processes

Grinding effect on levofloxacin hemihydrate

Similar Documents

Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry

Thermal Decomposition of Copper(I) Thiocarbamide Chloride Hemihydrate

Implications of Fine Grinding in Mineral Processing Mechanochemical approach

Effect of mechanical grinding on the reaction pathway and kinetics of the thermal decomposition of hydromagnesite

Effect of grinding on the dehydration behavior of nedocromil sodium hydrates

Thermal investigation of strontium acetate hemihydrate in nitrogen gas

Introduction—Polymer physics section

Study of dehydration and rehydration processes of portlandite in mature and young cement pastes

Improvement of surface cementitious properties of coarse fly ash by dehydration and rehydration processes

Grinding effect on levofloxacin hemihydrate