NDLI: Polymorphic screen and drug–excipient compatibility studies of the antichagasic benznidazole

Content Provider	Springer Nature Link
Author	Maximia, Flávia Pires vack, Kátia Monteiro Bahia, Maria Terezinha Sá Barreto, Lívia Lira Cunha Filho, Marcílio Sérgio Soares
Copyright Year	2011
Abstract	The purpose of this study was to investigate the polymorphism and compatibility of benznidazole (BNZ), a drug used in the treatment of Chagas disease. This drug was subjected to a polymorphic screen using a number of solvents and precipitation procedures to explore the possible existence of different crystal structures of BNZ. The compatibility of BNZ with selected pharmaceutical excipients was evaluated in binary mixtures, in a ratio of 1:1 (w/w). These results were then analyzed with a variety of techniques, including differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray powder diffractometry. No polymorphic forms of BNZ were detected despite some observed changes in the DSC profile. The thermal data indicate interaction of the drug with excipients hydroxyethylcellulose, polyethylene glycol, and hydroxypropyl-β-cyclodextrin. Additional studies using infrared spectroscopy confirm the incompatibility of BNZ with only the polyethylene glycol. This excipient should not be used in the development of solid dosage forms containing BNZ.
Starting Page	819
Ending Page	824
Page Count	6
File Format	PDF
ISSN	13886150
Journal	Journal of thermal analysis
Volume Number	106
Issue Number	3
e-ISSN	15728943
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-02-15
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Benznidazole Compatibility Differential scanning calorimetry Fourier transform infrared spectroscopy Polymorphism X-ray powder diffractometry Measurement Science and Instrumentation Physical Chemistry Polymer Sciences Inorganic Chemistry Analytical Chemistry
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

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