NDLI: Evaluation of thermal stability and parameters of dissolution of nifedipine crystals

Content Provider	Springer Nature Link
Author	Silva Leite, Renata Oliveira Macedo, Rui Torres, Sandro Marden Batista, Caio Cesar Neves Oliveira Baltazar, Lays Neto, Severi Antônio Lima Souza, Fábio Santos
Copyright Year	2012
Abstract	Nifedipine is a calcium channel blocker as well as a powerful vasodilator used to treat ischemic heart disease and hypertension. Its photosensitivity and very low solubility in water have been widely acknowledged as important properties deserving improvements. The main thrust of this study is to characterize the nature and the solid-state of nifedipine crystals obtained using different solvents as well as assess the stability by thermal methods (TG and DSC) and crystals structure by means of spectroscopic techniques (MID FTIR and XRD) and assess the dissolution parameters for such crystals. The calculated kinetic parameters activation energy (E $_{a}$ = 123.3 kJ mol$^{−1}$ ± 0.1), the factor frequency (A = 25.93 ± 0.9 min$^{−1}$), and the reaction order (n = 0.2) of the main stage of thermal decomposition of nifedipine raw material were performed according to the Ozawa model. The data showed a zero-order kinetic behavior for all crystals despite the different values of E $_{a}$ and A. The dissolution profiles were obtained for such crystals in three dissolution media with different pH values. After 1 h of dissolution, the higher amount of nifedipine dissolved was observed for crystals obtained in isopropyl alcohol (52.5 %, pH 4.5), followed by those in chloroform (48.1 %, pH 1.2) and subsequently in acetone (32.5 %, pH 6.8). Results showed different thermal stabilities and significant variations in the solubility of the crystals.
Starting Page	2117
Ending Page	2123
Page Count	7
File Format	PDF
ISSN	13886150
Journal	Journal of thermal analysis
Volume Number	111
Issue Number	3
e-ISSN	15728943
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-08-21
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nifedipine TG XRD Dissolution Physical Chemistry Analytical Chemistry Polymer Sciences Inorganic Chemistry Measurement Science and Instrumentation
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Condensed Matter Physics

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